INT131

Синонимы: INT-131, INT131 besylate, T131, 2-(2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropyl)-4H-chromen-4-one

INT131 is a synthetic, orally active small molecule that has drawn steady attention as a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator. Unlike full agonists such as rosiglitazone, INT131 is designed to bind PPARγ with high affinity while triggering a distinct transcriptional profile, which has made it a preferred tool compound for researchers exploring insulin sensitization with a reduced side-effect burden. In recent years, demand has grown among contract research organizations and metabolic disease labs looking for a reliable, well-characterized PPARγ modulator for in vitro and in vivo studies.

Chemically, INT131 belongs to the class of non-thiazolidinedione PPARγ ligands. It is synthesized through a multi-step organic route and is typically supplied as a white to off-white crystalline powder. The compound is freely soluble in common organic solvents like DMSO and ethanol, but shows limited aqueous solubility, a property that formulators often address through standard solubilization techniques when preparing dosing solutions.

LyvBio supplies INT131 with a purity of ≥98.0% as determined by HPLC, and each lot is accompanied by a full analytical package including NMR and mass spectrometry data. Our material is produced under strict quality control and is intended exclusively for research and further manufacturing use, not for direct human consumption.

Product Overview & Composition

INT131 is a single, synthetically derived chemical entity, not a mixture or extract. Its molecular formula is C21H23N3O4S, and it has a molecular weight of 413.49 g/mol. The compound is stable under normal storage conditions and should be protected from moisture and direct light. Because it is a research-grade active, we do not add any excipients or carriers unless a custom formulation is requested.

Applications & Product Lines

• Metabolic disease research: Used as a reference or test compound in studies of insulin resistance, type 2 diabetes, and lipid metabolism.
• PPARγ selectivity profiling: Helps differentiate full agonism from selective modulation in receptor binding and transactivation assays.
• Preclinical drug development: Serves as a lead molecule for structure-activity relationship (SAR) studies and analogue design.
• Chemical biology probes: Applied in target engagement and downstream gene expression experiments.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: Amber glass vials or foil bags, sealed under argon; custom packaging available on request.
• MOQ: 10 mg for research quantities; larger quantities negotiable.
• Срок выполнения заказа: 3-5 business days (stock items).
• Documentation: COA, MSDS, and TDS provided with every shipment.

Frequently Asked Questions

What is the minimum order quantity (MOQ) for INT131?

Our standard MOQ is 10 mg. For larger quantities, we can accommodate custom orders. Please contact our sales team for a quotation.

What is the delivery time?

For stock items, delivery is typically 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is available for each lot. We can also provide samples for evaluation upon request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.