Compound 7P

Синонимы: 7P, Compound 7P, 7-P, 7P compound, 1890208-58-8

In the fast-evolving landscape of epigenetic research, Compound 7P has emerged as a molecule of considerable interest among medicinal chemists and drug discovery scientists. As a potent inhibitor of the histone methyltransferase EZH2, it is widely used as a chemical probe to study chromatin remodeling, gene silencing, and their implications in cancer biology. Its popularity stems from its high selectivity and cellular activity, making it a valuable tool for both basic research and early-stage therapeutic development.

Compound 7P is a small-molecule inhibitor of EZH2, a component of the Polycomb repressive complex 2 (PRC2). It is chemically characterized as a substituted indole derivative with a molecular formula of C₁₈H₁₉N₃O₂ and a molecular weight of 309.36 g/mol. The compound is typically synthesized through multi-step organic reactions and is available as an off-white to light yellow crystalline powder. Its structure-activity relationship has been optimized to achieve nanomolar potency against both wild-type and mutant EZH2.

Our Compound 7P is produced under strict quality control and is standardized to ≥98% purity by HPLC. It is supplied as a crystalline solid, ensuring consistent performance in assay development and screening campaigns. With its excellent selectivity and cell permeability, Compound 7P is a reliable reference standard for epigenetic studies.

Product Overview & Composition

Compound 7P is a synthetic small molecule designed to selectively inhibit EZH2, an enzyme that catalyzes the methylation of histone H3 at lysine 27 (H3K27me3). This methylation mark is associated with transcriptional repression and is often dysregulated in various cancers, including lymphoma and breast cancer. By blocking EZH2 activity, Compound 7P induces apoptosis and inhibits proliferation in EZH2-dependent cell lines.

The compound is typically prepared via a convergent synthesis route involving indole functionalization and amide coupling. It is isolated as a single polymorphic form and is stable under recommended storage conditions. Each batch is thoroughly characterized by ¹H NMR, LC-MS, and elemental analysis to confirm identity and purity.

Key Applications

• Epigenetic research: Used as a chemical probe to study PRC2-mediated gene silencing and chromatin dynamics.
• Cancer biology: Investigated for its anti-proliferative effects in EZH2-mutant lymphomas and solid tumors.
• Drug discovery: Serves as a lead compound for the development of next-generation EZH2 inhibitors.
• Assay development: Employed as a positive control in H3K27me3 ELISA and cellular assays.
• Stem cell research: Explored for its role in modulating differentiation and self-renewal pathways.

Quality & Standards

Packaging & Supply

• Packaging: 10 mg, 50 mg, 100 mg, 500 mg, 1 g in amber glass vials with PTFE-lined caps; custom packaging available upon request.
• MOQ: 10 mg
• Срок выполнения заказа: 3-5 business days for stock items; 2-3 weeks for bulk orders.
• Documentation: COA, MSDS, TDS, and HPLC chromatogram provided with each shipment.

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