Citicoline Sodium

Синонимы: Citicoline sodium, CDP-Choline sodium, Cytidine 5′-diphosphocholine sodium, Cidilin sodium, Somazina, Recognan, Cytidine diphosphate choline monosodium salt

Citicoline sodium, also known as CDP-choline sodium, is a synthetic nucleotide derivative that plays a pivotal role in phospholipid metabolism. Structurally, it consists of a cytidine moiety linked to a choline via a diphosphate bridge, with sodium as the counterion. This unique architecture allows it to serve as an essential intermediate in the Kennedy pathway, the primary route for phosphatidylcholine biosynthesis in cell membranes. The presence of the sodium ion enhances its aqueous solubility and stability, making it suitable for pharmaceutical formulations.

In the realm of nootropics and neuroprotective agents, citicoline sodium has garnered significant attention for its ability to support cognitive function and neuronal health. It is commonly used in the treatment of stroke, traumatic brain injury, and age-related cognitive decline. As a bulk API, it is produced under strict GMP conditions to ensure high purity and consistent quality. Our citicoline sodium is manufactured via a proprietary enzymatic process, yielding a product that meets or exceeds USP/EP standards.

Beyond its clinical applications, citicoline sodium is also utilized in dietary supplements and functional foods aimed at enhancing memory and focus. Its excellent safety profile and well-documented efficacy make it a preferred ingredient for formulators targeting brain health. With a growing body of research supporting its benefits, citicoline sodium remains a cornerstone in the nutraceutical and pharmaceutical industries.

Chemical Structure & Properties

Citicoline sodium is a white crystalline powder with a molecular weight of 510.31 g/mol. It is highly soluble in water (up to 100 mg/mL) and practically insoluble in organic solvents like ethanol and acetone. The molecule is stable under normal storage conditions but should be protected from moisture and light. Its UV absorption maximum is at 280 nm, which is used for analytical identification.

Механизм действия

• Phosphatidylcholine synthesis: Citicoline sodium provides both cytidine and choline moieties, directly fueling the Kennedy pathway to increase phosphatidylcholine levels in neuronal membranes.
• Acetylcholine production: By supplying choline, it supports acetylcholine synthesis, enhancing cholinergic neurotransmission.
• Mitochondrial function: It helps maintain mitochondrial membrane integrity and ATP production, reducing oxidative stress.
• Neuroinflammation modulation: Citicoline sodium inhibits phospholipase A2 and reduces pro-inflammatory cytokine release.
• Dopamine receptor preservation: It preserves dopamine receptor density and function in ischemic conditions.

Quality Specifications

Supply & Documentation

• Capacity: 50 metric tons per year
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS, GMP certificate, DMF available upon request
• Packaging: 25 kg fiber drums with double polyethylene bags, or as per customer requirements

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