Biotinoyl Tripeptide-1

Синонимы: Biotinoyl Tripeptide-1, Biotin-GHK, Biotinoyl Gly-His-Lys, N-Biotinyl Tripeptide-1, Biotinoyl Tripeptide-1 (Cosmetic Peptide), CAS 299157-54-3

Biotinoyl Tripeptide-1 is a synthetic biotin-conjugated tripeptide with the sequence Gly-His-Lys (GHK), where biotin is attached to the N-terminus. This molecular design combines the regenerative properties of the GHK peptide with the hair and nail benefits of biotin. The peptide acts as a targeted delivery system, enhancing the penetration and stability of the GHK sequence, which is known to stimulate collagen synthesis, glycosaminoglycan production, and tissue repair. The biotin moiety also contributes to keratin infrastructure, making this peptide particularly effective in hair and nail care formulations.

Research indicates that Biotinoyl Tripeptide-1 can enhance extracellular matrix remodeling, improve hair follicle anchoring, and increase nail plate thickness. Its dual action on both skin and appendages makes it a versatile active for premium personal care products. The ingredient is compatible with a broad range of cosmetic ingredients and is stable in formulations with pH 4.0–7.0. For formulators seeking a multi-functional peptide with strong scientific backing, Biotinoyl Tripeptide-1 offers a compelling option.

Chemical Structure & Properties

Biotinoyl Tripeptide-1 is composed of three amino acids—glycine, histidine, and lysine—with a biotin group attached via an amide bond to the N-terminal glycine. The molecular formula is C24H38N6O6S, and the molecular weight is 538.66 g/mol. The presence of the biotin moiety increases lipophilicity, potentially improving skin penetration. The peptide is hygroscopic and should be stored under dry conditions. Its isoelectric point is approximately 9.5, and it is stable in aqueous solutions at neutral pH. The compound is typically synthesized as the trifluoroacetate salt to enhance solubility and stability.

Механизм действия

• Collagen stimulation: GHK sequence upregulates collagen types I, III, and VI, as well as elastin and proteoglycans, by activating fibroblasts.
• Biotin-mediated keratinization: Biotin is a cofactor for carboxylases involved in fatty acid synthesis and keratin production, strengthening hair and nails.
• Anti-inflammatory effects: GHK modulates cytokine release and reduces inflammation, promoting a healthier scalp and skin environment.
• Extracellular matrix remodeling: The peptide enhances glycosaminoglycan and fibronectin synthesis, improving skin firmness and hair follicle support.

Quality Specifications

Supply & Documentation

• Capacity: 50 kg per month
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1g, 10g, 100g, 1kg in amber glass vials or aluminum foil bags

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