5-Amino-1-methylquinolinium chloride

Synonyms: 5-Amino-1-methylquinolinium chloride, 1-Methyl-5-aminoquinolinium chloride, 5-Amino-1-methylquinolin-1-ium chloride, NSC 176327

In the evolving landscape of heterocyclic chemistry, 5-Amino-1-methylquinolinium chloride has emerged as a building block of considerable interest for pharmaceutical and agrochemical discovery programs. Its quinolinium core, functionalized with an amino group at the 5-position and a methyl group on the nitrogen, offers a versatile platform for derivatization, making it a valuable intermediate for researchers targeting kinase inhibitors, antimicrobial agents, and fluorescent probes.

5-Amino-1-methylquinolinium chloride is a quaternary ammonium salt derived from 5-aminoquinoline through N-methylation. The permanent positive charge on the nitrogen enhances water solubility and facilitates interactions with biological targets, while the amino group provides a handle for further functionalization via acylation, alkylation, or diazotization. This dual functionality makes it a strategic starting material for constructing complex molecular architectures.

LyvBio supplies 5-Amino-1-methylquinolinium chloride with a purity of ≥98% (HPLC), ensuring consistent performance in demanding synthetic routes. Each batch is rigorously tested to meet strict quality standards, supported by comprehensive documentation for seamless integration into your R&D and production workflows.

Product Overview & Composition

5-Amino-1-methylquinolinium chloride is a small molecule with the molecular formula C10H11ClN2 and a molecular weight of 194.66 g/mol. It appears as a yellow to orange crystalline powder that is readily soluble in polar solvents such as water and methanol. The compound’s structure combines a quinolinium cation with a chloride counterion, imparting unique electronic properties that are advantageous in various chemical transformations.

The presence of the amino group at the 5-position allows for selective reactions, enabling the introduction of diverse substituents without affecting the quinolinium core. This regioselectivity is particularly valuable in medicinal chemistry, where precise modifications can lead to improved potency and pharmacokinetic profiles.

Key Applications

• Pharmaceutical intermediates: Used in the synthesis of kinase inhibitors, antimicrobials, and anticancer agents, where the quinolinium scaffold contributes to target binding.
• Agrochemical development: Serves as a precursor for herbicides and fungicides, leveraging the biological activity of quinolinium derivatives.
• Dye and fluorescent probe synthesis: The conjugated system and amino group enable the design of fluorescent tags for bioimaging and sensing applications.
• Material science: Employed in the preparation of organic semiconductors and electron-transport materials due to its redox properties.
• Chemical research: Acts as a model compound for studying quaternary ammonium salt reactivity and photophysical behavior.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg fiber drums with double polyethylene bags, customizable packaging available upon request.
• MOQ: 1 kg for pilot studies; larger quantities for scale-up.
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS provided with each shipment.

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