BAM 15

Синонимы: BAM 15, 2-[(4-Methoxyphenyl)sulfonyl]-N-(4-methylphenyl)acetamide, N-(4-Methylphenyl)-2-[(4-methoxyphenyl)sulfonyl]acetamide, BAM-15, Mitochondrial Uncoupler BAM 15

In the ongoing search for effective mitochondrial uncouplers with drug-like properties, BAM 15 has emerged as a molecule of considerable interest. Unlike classical protonophores such as 2,4-dinitrophenol (DNP), which carry significant toxicity risks, BAM 15 offers a milder, more controlled approach to modulating cellular energy metabolism. This has positioned it as a popular tool compound in metabolic research, particularly in studies related to obesity, insulin resistance, and non-alcoholic steatohepatitis (NASH). Its popularity has grown alongside the broader interest in mitochondrial dysfunction as a therapeutic target, making it a staple in both academic and industrial laboratories.

BAM 15 is a synthetic small molecule that acts as a mitochondrial protonophore. It is chemically distinct from DNP, featuring a sulfonamide-based structure that contributes to its improved safety profile. The compound is typically synthesized through a multi-step organic process, resulting in a high-purity white to off-white crystalline powder. Its mechanism of action involves the transport of protons across the inner mitochondrial membrane, thereby dissipating the proton gradient and uncoupling oxidative phosphorylation from ATP synthesis. This leads to increased energy expenditure and enhanced substrate oxidation, which are the basis for its metabolic effects.

At LyvBio, we supply BAM 15 with a purity of ≥98% (HPLC), ensuring consistency and reliability for your research needs. Our product is manufactured under strict quality control measures and is accompanied by comprehensive documentation, including a Certificate of Analysis (COA), MSDS, and TDS. Whether you are investigating mitochondrial function, screening for anti-obesity agents, or exploring the compound’s potential in other therapeutic areas, our BAM 15 provides a dependable foundation for your experiments.

Product Overview & Composition

BAM 15 (CAS 210302-17-3) is a synthetic organic compound with the molecular formula C19H22N2O2S and a molecular weight of 342.46 g/mol. It is characterized by a 4-methoxyphenylsulfonyl group attached to an acetamide moiety, which is further substituted with a p-tolyl group. This unique structure confers its protonophoric activity and influences its physicochemical properties, such as solubility and membrane permeability.

The compound is lipophilic, with a calculated logP of approximately 3.2, allowing it to readily partition into biological membranes. It is soluble in common organic solvents like DMSO and ethanol but has limited aqueous solubility. This solubility profile is typical for mitochondrial uncouplers and necessitates the use of appropriate vehicles (e.g., DMSO or corn oil) in in vivo studies. BAM 15 is stable under recommended storage conditions and should be protected from light and moisture to maintain its integrity.

Key Applications

• Исследования в области метаболизма: BAM 15 is widely used to study mitochondrial uncoupling and its effects on energy homeostasis, glucose metabolism, and lipid oxidation. It serves as a tool to investigate the role of mitochondrial dysfunction in obesity and type 2 diabetes.
• Obesity and NASH models: In preclinical models, BAM 15 has been shown to reduce adiposity and improve hepatic steatosis, making it a valuable compound for evaluating new therapies for non-alcoholic steatohepatitis (NASH) and related metabolic disorders.
• Mitochondrial function assays: Researchers employ BAM 15 to modulate mitochondrial membrane potential and assess the impact on cellular respiration, ROS production, and ATP synthesis.
• Drug discovery: As a reference compound, BAM 15 is used in high-throughput screening to identify novel uncouplers or to benchmark the efficacy and safety of candidate molecules.
• Neuroprotection studies: Emerging evidence suggests that mild uncoupling may have neuroprotective effects; BAM 15 is used in exploratory research on neurodegenerative diseases.

Quality & Standards

Packaging & Supply

• Packaging: BAM 15 is available in amber glass vials with PTFE-lined caps, packaged under argon to prevent oxidation. Standard sizes include 10 mg, 50 mg, 100 mg, 500 mg, and 1 g. Bulk quantities can be provided in foil bags or as requested.
• MOQ: The minimum order quantity is 10 mg, making it accessible for small-scale research. For larger quantities, please inquire for pricing and availability.
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: Each shipment includes a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and Technical Data Sheet (TDS). Additional documentation, such as stability data or custom testing, can be provided upon request.

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