Palmitoyl Tripeptide-38

Synonyms: Palmitoyl Tripeptide-38, N-Palmitoyl Tripeptide-38, Palmitoyl Tripeptide-38 Acetate, C16-Tripeptide-38

Palmitoyl Tripeptide-38 is a synthetic lipopeptide that combines a short peptide sequence with a palmitic acid (C16) tail. The peptide portion, typically composed of three amino acids, is designed to mimic a fragment of the laminin-5 protein, which plays a critical role in dermal-epidermal junction (DEJ) integrity. The palmitoyl chain enhances lipophilicity, facilitating penetration through the stratum corneum and improving bioavailability in skin tissue.

This molecule is produced via solid-phase peptide synthesis (SPPS), followed by N-terminal palmitoylation. It is commercially available as a white to off-white powder with high purity (≥95% by HPLC). Palmitoyl Tripeptide-38 is a key active ingredient in advanced anti-aging and skin-repair formulations, often incorporated into serums, creams, and essences targeting wrinkle reduction and skin firmness.

Research indicates that Palmitoyl Tripeptide-38 stimulates the synthesis of key extracellular matrix (ECM) components, including collagen I, III, IV, fibronectin, and hyaluronic acid, by activating the laminin-5 pathway. This makes it a valuable peptide for cosmetic and pharmaceutical applications aimed at restoring skin structure and combating chronological and photoaging.

Chemical Structure & Properties

Palmitoyl Tripeptide-38 is characterized by a tripeptide sequence (e.g., palmitoyl-Lys-Val-Lys) linked to palmitic acid via an amide bond. The molecular formula is C₃₃H₆₂N₆O₆ with a molecular weight of 662.9 g/mol. The lipophilic palmitoyl group enhances skin penetration, while the hydrophilic peptide moiety interacts with cellular targets. It is soluble in water, ethanol, and hydroglycolic solutions, and should be stored under cool, dry conditions to maintain stability.

Mechanism of Action

• Laminin-5 stimulation: Palmitoyl Tripeptide-38 upregulates laminin-5, a key protein in the dermal-epidermal junction, promoting structural cohesion.
• ECM component synthesis: It boosts collagen I, III, IV, fibronectin, and hyaluronic acid production, improving skin density and elasticity.
• Wrinkle reduction: By reinforcing the DEJ and ECM, it visibly reduces wrinkle depth and improves skin smoothness.
• Skin repair: Accelerates recovery processes, making it suitable for post-procedure and sensitive skin care.

Quality Specifications

Supply & Documentation

• Capacity: 10 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 10 g, 100 g in amber glass vials, or customized packaging

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com