Palmitoyl Pentapeptide-4

Synonyms: Pal-GQPR, Palmitoyl-Gly-Gln-Pro-Arg, Matrixyl 3000 Component, N-Palmitoyl-Glycyl-L-Glutaminyl-L-Prolyl-L-Arginine, Palmitoyl Pentapeptide-3, Matrixyl

Palmitoyl Pentapeptide-4 is a synthetic lipopeptide that has become a staple in advanced anti-aging formulations. Its structure features a palmitic acid moiety conjugated to the N-terminus of the pentapeptide sequence glycine-glutamine-proline-arginine (GQPR), a fragment derived from the procollagen I alpha-1 chain. This lipophilic modification enhances skin penetration, allowing the peptide to reach deeper layers of the epidermis where it can exert its biological effects. Since its introduction in the early 2000s, it has been widely studied for its ability to support collagen synthesis and improve the appearance of aging skin.

The mechanism of action involves the stimulation of collagen types I, III, and IV, as well as fibronectin and hyaluronic acid production. Unlike topical retinoids that can cause irritation, Palmitoyl Pentapeptide-4 offers a gentler alternative with a favorable safety profile. It is often combined with other peptides, such as Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, to create synergistic anti-aging complexes. Its efficacy has been validated in numerous in vitro and clinical studies, demonstrating visible reductions in wrinkle depth and improved skin texture.

As a cosmetic ingredient, Palmitoyl Pentapeptide-4 is typically supplied as a high-purity powder (≥95% HPLC) that is easily incorporated into emulsions, serums, and gels. It is compatible with a broad range of formulation ingredients and is stable under normal storage conditions. The recommended usage level ranges from 1% to 5%, depending on the desired effect and the specific product format. Its versatility and proven performance make it a valuable asset for formulators targeting the premium anti-aging market.

Function

• Collagen stimulation: Upregulates collagen I, III, and IV synthesis, improving skin firmness and elasticity.
• Wrinkle reduction: Clinically shown to reduce the depth of fine lines and wrinkles.
• Extracellular matrix support: Promotes fibronectin and hyaluronic acid production for enhanced skin hydration.
• Skin repair: Accelerates wound healing and improves overall skin texture.
• Anti-aging: Delays the visible signs of aging by supporting dermal structure.

Source & Standardization

• Source: Synthetic peptide, produced via solid-phase peptide synthesis.
• Purity: ≥95% (HPLC).
• Form: White to off-white powder.
• Solubility: Water-soluble, also soluble in ethanol and glycols.
• Applications: Anti-aging creams, serums, lotions, and other cosmetic formulations.

Specifications

Documentation & Supply

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 10 g, 100 g, or 1 kg in amber glass bottles or aluminum foil bags

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com