Palmitoyl Pentapeptide-4

Synonyms: Palmitoyl Pentapeptide-4, Matrixyl, Pal-KTTKS, N-palmitoyl-Lys-Thr-Thr-Lys-Ser, Palmitoyl pentapeptide

Palmitoyl Pentapeptide-4 is a synthetic peptide that has become a cornerstone in anti-aging skincare. It consists of a palmitic acid chain attached to the N-terminus of the pentapeptide Lys-Thr-Thr-Lys-Ser (KTTKS). This lipophilic modification enhances its skin penetration and stability, allowing the peptide to reach the dermal layer where it exerts its effects. The peptide sequence itself is derived from the procollagen I fragment, which is a natural substrate in collagen synthesis.

Palmitoyl Pentapeptide-4 is typically supplied as a white to off-white powder with high purity (≥98% by HPLC). It is soluble in water and ethanol, making it easy to incorporate into various cosmetic bases. For manufacturers, it offers a reliable and effective active ingredient with a well-documented efficacy profile, supported by numerous clinical studies.

Mechanism of Action

• Collagen stimulation: The KTTKS sequence mimics the natural cleavage product of procollagen I, which triggers fibroblasts to increase collagen production.
• Matrix remodeling: By promoting collagen synthesis, it helps restore the extracellular matrix, improving skin elasticity and firmness.
• Wrinkle reduction: Increased collagen density leads to a visible reduction in the depth and volume of fine lines and wrinkles.
• Skin barrier enhancement: It also supports the production of other matrix proteins, such as fibronectin and glycosaminoglycans, contributing to overall skin health.

Quality Specifications

Loss on Drying≤5%

Supply & Documentation

• MOQ: 5g
• Capacity: 10 kg per month
• Lead time: 3-5 days for stock items, 10-15 days for production
• Documentation: COA, MSDS, TDS, and allergen statement available upon request
• Packaging: Double polyethylene bags inside aluminum foil bag, or customized per client’s request

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com