O-304

O-304

Product Name O-304
CAS Number 1261289-04-6
Synonyms O-304, O304, O 304
Molecular Formula C19H19N3O2S
Molecular Weight 353.44 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98.0%
Solubility Soluble in DMSO (≥10 mg/mL), slightly soluble in ethanol, practically insoluble in water
Storage Store at -20°C, protected from light and moisture
Package 10 mg, 50 mg, 100 mg, 500 mg, 1 g in amber glass vials

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O-304 Structure

Synonyms: O-304, O304, O 304, 5-[[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenyl]methyl]-1,3-thiazolidine-2,4-dione

O-304 is a synthetic small-molecule AMPK activator developed for metabolic research. It is manufactured under strict quality control and supplied as a high-purity crystalline powder, typically ≥98% by HPLC. The compound is designed to selectively activate AMPK, a key regulator of cellular energy homeostasis, making it a valuable tool for studying metabolic disorders.

With its favorable pharmacokinetic profile and oral bioavailability demonstrated in preclinical models, O-304 has attracted interest in the research community for its potential in addressing insulin resistance, type 2 diabetes, and related metabolic conditions. It is intended for laboratory and research use only, not for human or veterinary consumption.

Product Highlights

  • High Purity: ≥98% as determined by HPLC, ensuring reliable experimental results.
  • Selective AMPK Activation: Directly activates AMPK without affecting related kinases, providing specificity.
  • Preclinical Validation: Shown to improve insulin sensitivity and glucose uptake in animal models.
  • Scalable Supply: Available in gram to kilogram quantities to support research and early development.
  • Comprehensive Documentation: Each batch comes with a COA, MSDS, and TDS for full traceability.
  • Custom Packaging: Offered in amber vials under inert gas to ensure stability.

Applications

  • Metabolic disease research, including type 2 diabetes and obesity.
  • Studies on AMPK signaling pathways and energy metabolism.
  • Preclinical drug discovery for insulin sensitizers.
  • Investigation of cellular stress responses and autophagy.
  • Reference standard for analytical method development.

Specifications

Parameter Specification
Purity (HPLC) ≥98.0%
Appearance White to off-white powder
Identification NMR, MS conform to structure
Loss on Drying ≤0.5%
Residue on Ignition ≤0.1%
Heavy Metals ≤10 ppm
Storage -20°C, protected from light

Ordering & Supply

  • Packaging: Amber glass vials with PTFE-lined caps, under argon.
  • MOQ: 10 mg; bulk quantities available upon request.
  • Lead time: 3-5 business days for in-stock items; 2-3 weeks for custom synthesis.
  • Documentation: COA, MSDS, TDS provided with each shipment.
  • Shipping: Ambient or refrigerated, depending on destination.

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