N-Acetyl-L-Cysteine

N-Acetyl-L-Cysteine

Product Name N-Acetyl-L-Cysteine
CAS Number 616-91-1
Appearance White crystalline powder
Assay (HPLC) 98.0% – 102.0%
Molecular Formula C5H9NO3S
Molecular Weight 163.19 g/mol
Loss on Drying ≤ 1.0%
Heavy Metals ≤ 10 ppm
Solubility Soluble in water and ethanol
Package 25 kg fiber drum with double polyethylene liner

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Synonyms: N-Acetylcysteine, NAC, Acetylcysteine, L-α-Acetamido-β-mercaptopropionic acid, N-Acetyl-3-mercaptoalanine, LNAC

N-Acetyl-L-Cysteine (NAC) has become a staple in respiratory, immune, and antioxidant formulations worldwide. Demand keeps climbing as formulators look for a stable, bioavailable cysteine derivative that supports glutathione production and offers mucolytic action without the instability of free L-cysteine.

NAC is the acetylated form of the amino acid L-cysteine. The acetyl group shields the thiol from oxidation, improving stability and allowing the molecule to deliver cysteine intracellularly, where it is used to synthesize glutathione—the body’s master antioxidant. It appears as a white crystalline powder with a mild acetic odor and is freely soluble in water.

LyvBio supplies N-Acetyl-L-Cysteine with a minimum assay of 98.0% (HPLC), meeting EP, USP, and AJI standards. Our material is manufactured under cGMP conditions, with full traceability and documentation for pharmaceutical, nutraceutical, and food applications.

Product Overview & Composition

N-Acetyl-L-Cysteine is a thiol-containing compound with the molecular formula C5H9NO3S and a molecular weight of 163.19 g/mol. The acetyl group protects the sulfhydryl from oxidation, which enhances stability and allows the molecule to be absorbed intact before being deacetylated to release free cysteine. This cysteine then serves as the rate-limiting substrate for glutathione synthesis.

Key Applications

  • Respiratory health: NAC acts as a mucolytic agent, breaking disulfide bonds in mucus to reduce viscosity and ease clearance in conditions like bronchitis and COPD.
  • Antioxidant and detox support: It replenishes intracellular glutathione, supporting liver detoxification and protecting against oxidative stress.
  • Immune function: NAC modulates immune responses and is used in formulations targeting immune resilience.
  • Pharmaceutical formulations: Used in effervescent tablets, sachets, and injectables for acetaminophen overdose and respiratory indications.
  • Nutraceuticals: Found in capsules, powders, and functional beverages aimed at overall wellness and antioxidant defense.

Quality & Standards

Parameter Specification
Assay (HPLC) 98.0% – 102.0%
Loss on Drying ≤ 1.0%
Heavy Metals ≤ 10 ppm
Microbial Limits Total aerobic count ≤ 1000 CFU/g; Yeast & Mold ≤ 100 CFU/g; E. coli absent
Residue on Ignition ≤ 0.1%

Packaging & Supply

  • Packaging: 25 kg fiber drums with double polyethylene liners, or as requested.
  • MOQ: 25 kg.
  • Lead time: 3-5 business days (stock items)
  • Documentation: COA, MSDS, TDS, and regulatory support available upon request.

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