Myristoyl Tetrapeptide-12

Synonyms: Myristoyl Tetrapeptide-12, N-Myristoyl Tetrapeptide-12, Myristoyl Tetrapeptide-12 (INCI), CAS 959610-54-9

Myristoyl Tetrapeptide-12 is a synthetic lipopeptide consisting of a tetrapeptide backbone acylated with myristic acid at the N-terminus. The sequence—typically comprising glycine, histidine, and lysine residues—is designed to mimic the active site of human parathyroid hormone-related protein (PTHrP), a natural regulator of melanogenesis. This modification enhances lipophilicity and skin penetration, making it a valuable active in cosmetic formulations aimed at pigmentation control.

Since its introduction, Myristoyl Tetrapeptide-12 has gained attention as a non-hydroquinone alternative for hyperpigmentation. It operates by interfering with tyrosinase activity and melanocyte-stimulating hormone (MSH) signaling, thereby reducing melanin synthesis. Unlike conventional whitening agents, it does not cause cytotoxicity to melanocytes, offering a gentler approach to skin lightening.

The peptide is produced via solid-phase peptide synthesis, followed by myristoylation and high-performance liquid chromatography (HPLC) purification. It is supplied as a white to off-white powder, standardized to ≥98% purity, and is compatible with a wide range of cosmetic delivery systems, including emulsions, serums, and gels.

Function

• Melanin inhibition: Reduces tyrosinase activity and melanin production in melanocytes.
• Skin brightening: Diminishes hyperpigmentation and evens skin tone.
• Anti-inflammatory: Modulates inflammatory mediators in the skin.
• Collagen stimulation: May promote collagen synthesis for improved skin texture.
• Antioxidant protection: Scavenges free radicals to prevent oxidative stress.

Source & Standardization

• Source: Synthetic peptide produced by solid-phase peptide synthesis.
• Extraction: Not applicable (synthetic).
• Standardization: ≥98% purity by HPLC.
• Forms: White to off-white powder.
• Applications: Skin care products, serums, creams, and lotions for hyperpigmentation and anti-aging.

Specifications

Documentation & Supply

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com