Hydroxypinacolone Retinoate

Synonyms: Granactive Retinoid, HPR, Hydroxypinacolone Retinoate, Retinoic Acid Ester, all-trans-Retinoic Acid Ester with Hydroxypinacolone

Hydroxypinacolone Retinoate (HPR) is a high-performance retinoid ester that has been generating considerable interest in the personal care and pharmaceutical industries. Unlike conventional retinol, HPR is a ester of all-trans-retinoic acid and hydroxypinacolone, a branched-chain alcohol. This molecular design not only enhances stability but also allows for direct biological activity without the need for metabolic conversion. Since its introduction, HPR has become a key ingredient in premium anti-aging formulations, prized for its ability to deliver retinoic acid-like benefits with reduced irritation potential.

From a chemical standpoint, HPR belongs to the class of retinoids, which includes retinol, retinal, and retinoic acid. The ester linkage in HPR is crucial: it masks the carboxylic acid group of retinoic acid, improving lipophilicity and skin penetration. Once absorbed, HPR can interact with retinoic acid receptors (RARs) directly, bypassing the oxidative conversion steps required by retinol. This direct receptor binding is thought to underlie its efficacy in modulating gene expression related to cell proliferation, differentiation, and extracellular matrix production. Compared to retinoic acid, HPR exhibits a more favorable safety profile, making it suitable for a wider range of skin types.

In the market, HPR is typically offered as a high-purity crystalline powder, with assay values of 95% or higher. It is commonly incorporated into anti-aging serums, creams, and lotions at concentrations ranging from 0.1% to 1%. Beyond cosmetics, HPR is also explored in dermatological research for its potential in treating acne, psoriasis, and photoaging. Its compatibility with other actives, such as niacinamide and peptides, further expands its formulation versatility. As consumer demand for effective yet gentle retinoids grows, HPR stands out as a compelling active ingredient for next-generation skincare products.

Function

• Anti-aging activity: Reduces fine lines and wrinkles by promoting collagen synthesis and cell turnover.
• Retinoid receptor binding: Directly activates RARs, leading to retinoic acid-like gene expression changes.
• Acne management: Helps unclog pores and reduce inflammation associated with acne vulgaris.
• Antioxidant protection: Scavenges free radicals, mitigating oxidative stress in skin cells.
• Skin tone improvement: Evens out pigmentation and enhances overall skin texture.

Source & Standardization

• Source: Synthetic esterification of all-trans-retinoic acid with hydroxypinacolone.
• Extraction: Not applicable; produced via chemical synthesis.
• Standardization: ≥95.0% (HPLC).
• Forms: White to off-white crystalline powder.
• Applications: Anti-aging skincare, acne treatments, dermatological research, cosmetic formulations.

Specifications

Documentation & Supply

• Monthly capacity: 500 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com