Amoxicillin Sodium

Synonyms: Amoxicillin sodium salt, Sodium amoxicillin, Amoxicillin sodium sterile, D-(-)-α-Amino-p-hydroxybenzylpenicillin sodium, BRL-2333 sodium

Amoxicillin Sodium is the sodium salt form of amoxicillin, a broad-spectrum aminopenicillin antibiotic. Unlike the more common amoxicillin trihydrate, this sodium salt is highly water-soluble, making it the preferred choice for injectable formulations and other liquid applications where rapid dissolution and bioavailability are critical. It is a white to off-white crystalline powder, freely soluble in water and practically insoluble in ethanol and ether.

Chemically, Amoxicillin Sodium is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt, with a molecular formula of C16H18N3NaO5S and a molecular weight of 387.39 g/mol. It is derived from the penicillin nucleus, 6-aminopenicillanic acid, and shares the typical beta-lactam structure responsible for its antibacterial activity.

Because of its improved solubility profile, Amoxicillin Sodium is widely used in parenteral preparations, often in combination with beta-lactamase inhibitors such as clavulanic acid. It is also employed in veterinary medicine and in research settings where a water-soluble form of amoxicillin is required. The compound is typically standardized to an assay of 95.0% to 102.0% (HPLC, calculated on anhydrous basis) and is available in sterile and non-sterile grades.

Function & Mechanism

• Antibacterial activity: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death.
• Broad-spectrum coverage: Effective against a wide range of Gram-positive and Gram-negative bacteria, including Streptococcus, Staphylococcus, E. coli, and Haemophilus influenzae.
• Beta-lactamase susceptibility: Like other penicillins, it is susceptible to hydrolysis by beta-lactamases; combining with beta-lactamase inhibitors extends its spectrum.
• Rapid absorption: When administered orally, it is rapidly absorbed, but the sodium salt is primarily used for injectable routes due to its high solubility.

Source & Standardization

• Source: Semi-synthetic, derived from 6-aminopenicillanic acid (6-APA) through chemical modification.
• Manufacturing: Produced by reacting amoxicillin trihydrate with sodium salt, followed by purification and drying.
• Standardization: Assay 95.0% – 102.0% (HPLC, anhydrous basis).
• Forms: White to off-white crystalline powder; sterile and non-sterile grades available.
• Applications: Injectable antibiotics, veterinary formulations, research and development.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 10 metric tons
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double polyethylene liners

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Amoxicillin Sodium?

Our standard MOQ is 1 kg. For larger quantities, please contact us for pricing and availability.

What is the delivery time?

For stock items, delivery is typically 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request; please contact us for details.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.