| Product Name | 2'-Deoxyadenosine |
| CAS Number | 958-09-8 |
| Molecular Formula | C₁₀H₁₃N₅O₃ |
| Molecular Weight | 251.24 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥ 99.0% |
| Melting Point | 185–189°C (dec.) |
| Specific Rotation ([α]²⁰D) | -24° to -28° (c=0.5, H₂O) |
| Loss on Drying | ≤ 0.5% |
| Heavy Metals | ≤ 10 ppm |
| Storage | Cool, dry, sealed |
| Shelf Life | 36 months |
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2′-Deoxyadenosine is a deoxyribonucleoside composed of adenine (a purine base) attached to a 2′-deoxyribose sugar. It is one of the four fundamental building blocks of DNA (deoxyribonucleic acid), where it pairs with thymidine (dT) via two hydrogen bonds.
As a natural DNA constituent, 2′-deoxyadenosine is essential for DNA synthesis and repair. In pharmaceutical and research applications, it serves as a key intermediate for the synthesis of antiviral drugs (e.g., vidarabine, fludarabine), anticancer agents, and modified nucleoside analogs.
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥ 99.0% | HPLC |
| Appearance | White to off-white crystalline powder | Visual |
| Identification | HPLC retention time (match reference) | HPLC |
| Melting Point | 185–189°C (dec.) | USP <741> |
| Specific Rotation ([α]²⁰D) | -24° to -28° (c=0.5, H₂O) | Polarimetry |
| Loss on Drying | ≤ 0.5% | USP <731> |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
| Water (Karl Fischer) | ≤ 0.5% | USP <921> |
| Related Substances | Single impurity ≤ 0.5%; Total ≤ 1.0% | HPLC |
| Purity by TLC | ≥ 99.0% | HPLC |
LyvBio Co., Ltd. is a GMP-certified supplier of high-purity 2′-Deoxyadenosine for the pharmaceutical, biotechnology, and research industries.
Supply capabilities:
Purity: ≥99.0% (HPLC)
Monthly capacity: 100+ kg
Bulk quantities: 10g – 100kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS, TDS, HPLC chromatogram, optical rotation, stability data
Q: What is the difference between 2′-Deoxyadenosine and Adenosine?
A: 2′-Deoxyadenosine has a hydrogen (-H) at the 2′-position of the sugar; adenosine has a hydroxyl group (-OH). This makes 2′-deoxyadenosine a DNA building block and adenosine an RNA building block. Adenosine is also a nutraceutical supplement; 2′-deoxyadenosine is primarily a pharmaceutical intermediate.
Q: Is 2′-Deoxyadenosine a dietary supplement?
A: No. Unlike adenosine or nicotinamide riboside, 2′-deoxyadenosine is not marketed as a dietary supplement. It is a pharmaceutical intermediate and research chemical.
Q: How is 2′-Deoxyadenosine synthesized?
A: Commercially, it is produced by enzymatic or chemical deoxygenation of adenosine, or via chemical synthesis from adenine and 2′-deoxyribose derivatives.
Q: What is the typical purity required for pharmaceutical use?
A: ≥99.0% (HPLC) with individual impurities ≤0.5% and total impurities ≤1.0%. LyvBio meets this specification.
Q: Can 2′-Deoxyadenosine be used in PCR?
A: Indirectly. The phosphorylated form (dATP) is a component of dNTP mixes for PCR. 2′-Deoxyadenosine itself is not directly used; it requires enzymatic or chemical phosphorylation to dATP.
Q: What is the most common impurity in 2′-Deoxyadenosine?
A: Adenine (free base) from hydrolysis, and adenosine (incomplete deoxygenation). LyvBio controls both to ≤0.2%.
Q: What is your MOQ?
A: Research samples: 10g–100g. Trial production: 500g–5kg. Commercial: Negotiable (10kg+ receives volume pricing). Lead time: 3–5 days (samples); 10–15 days (bulk).
Need high-purity 2′-Deoxyadenosine for pharmaceutical synthesis or research?
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
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