Pyridoxine hydrochloride

Pyridoxine hydrochloride

Nazwa produktu Pyridoxine hydrochloride
Numer CAS 58-56-0
Inne nazwy Vitamin B6 hydrochloride, Pyridoxol hydrochloride, 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
Wzór cząsteczkowy C8H11NO3·HCl
Masa cząsteczkowa 205.64 g/mol
Wygląd White to almost white crystalline powder
Oznaczenie (HPLC) 98.0%–102.0% (on dried basis)
Strata przy suszeniu ≤0.5%
Popiół po spaleniu ≤0,11 TP3T
Metale ciężkie ≤10 ppm
Rozpuszczalność Freely soluble in water, slightly soluble in ethanol, practically insoluble in ether
Opakowanie Beczka na włókna o pojemności 25 kg z podwójną wkładką z polietylenu

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Pyridoxine hydrochloride Structure

Synonyms: Vitamin B6 hydrochloride, Pyridoxol hydrochloride, 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride, Aderoxine, Hexa-Betalin, Pyridoxinium chloride

Pyridoxine hydrochloride is the synthetic hydrochloride salt of pyridoxine (vitamin B6), a water-soluble vitamin that plays an essential role in amino acid metabolism, neurotransmitter synthesis, and hemoglobin production. Unlike the other B6 vitamers—pyridoxal and pyridoxamine—pyridoxine is the most stable and commonly used form in pharmaceutical and nutritional applications. Its hydrochloride salt further enhances stability and aqueous solubility, making it the preferred choice for oral solid dosage forms, injectables, and fortified foods.

First isolated in the 1930s and chemically synthesized shortly thereafter, pyridoxine hydrochloride has become a staple in clinical nutrition and preventive medicine. It serves as a precursor to pyridoxal 5′-phosphate (PLP), the biologically active coenzyme that catalyzes over 140 enzymatic reactions, including transamination, decarboxylation, and racemization. This central role in nitrogen metabolism explains its widespread use in treating deficiencies, alleviating nausea during pregnancy, and managing certain types of anemia and neuropathy.

In the pharmaceutical industry, pyridoxine hydrochloride is formulated into tablets, capsules, and sterile solutions, often in combination with other B-complex vitamins. It is also a key ingredient in energy drinks, infant formula, and dietary supplements, where it supports normal neurological function and red blood cell formation. Its well-documented safety profile and excellent stability make it a reliable choice for formulators worldwide.

Funkcja

  • Coenzyme precursor: Converts to pyridoxal 5′-phosphate (PLP), essential for amino acid and neurotransmitter metabolism.
  • Neurological support: Aids in the synthesis of serotonin, dopamine, and GABA, supporting mood and nerve function.
  • Hematopoietic activity: Plays a role in hemoglobin synthesis and prevention of sideroblastic anemia.
  • Nausea management: Clinically used to alleviate nausea and vomiting during pregnancy, often with doxylamine.
  • Funkcja odpornościowa: Supports lymphocyte proliferation and antibody production.
  • Homocysteine regulation: Helps maintain normal homocysteine levels, supporting cardiovascular health.

Source & Standardization

  • Źródło: Synthetic chemical synthesis
  • Production: Multi-step organic synthesis followed by hydrochloride salt formation and purification
  • Standardization: 98.0%–102.0% (HPLC, on dried basis)
  • Forms: White crystalline powder
  • Zastosowania: Pharmaceutical tablets, capsules, injectables, dietary supplements, food fortification, animal feed

Dane techniczne

Parametr Specyfikacja
Oznaczenie (HPLC) 98.0%–102.0%
Identyfikacja IR absorption complies
Strata przy suszeniu ≤0.5%
Popiół po spaleniu ≤0,11 TP3T
Metale ciężkie ≤10 ppm
Wartości graniczne dla mikroorganizmów Total aerobic count ≤1000 CFU/g; Yeast & Mold ≤100 CFU/g; E. coli absent

Documentation & Supply

  • Miesięczna wydajność: 50 metric tons
  • Czas realizacji: 3–5 dni roboczych (towary dostępne w magazynie)
  • Dokumentacja: COA, MSDS, TDS, GMP, ISO 9001, Halal, Kosher
  • Opakowanie: 25 kg fiber drum with double polyethylene liner, or as per customer request

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