Sodium Taurocholate

Synonyms: Taurocholic acid sodium salt, Sodium cholyltaurine, Sodium taurocholate hydrate, TCA sodium salt, Cholyltaurine sodium, N-Choloyltaurine sodium salt

Sodium taurocholate is the sodium salt of taurocholic acid, a primary bile acid conjugated with the amino sulfonic acid taurine. In the human body it is synthesized in the liver from cholesterol via the classical and alternative bile acid pathways, then secreted into bile to facilitate the absorption of dietary fats and fat-soluble vitamins. It is one of the most abundant bile salts in human and bovine bile, which is why it has been isolated and used in biochemical research and pharmaceutical formulation for well over a century.

Structurally, sodium taurocholate belongs to the family of taurine-conjugated bile acids, distinguished by a sulfonate head group that remains ionized across a wide pH range. This gives the molecule a strong anionic character and exceptional water solubility compared with unconjugated bile acids such as cholic acid or chenodeoxycholic acid. The steroid nucleus carries three hydroxyl groups (3α, 7α, 12α), and the side chain terminates in a taurine amide, a combination that underpins its powerful detergent properties and its physiological role in micelle formation.

Commercial sodium taurocholate is typically produced by conjugation or extraction, then purified to a well-defined assay and supplied as a white crystalline powder. It is widely used as a solubilizing agent for lipophilic compounds, as a component of cell culture media, in bile acid metabolism studies, and as a reference standard for analytical method development. Because it is a natural, biodegradable surfactant, it also attracts interest in drug delivery and formulation work where synthetic surfactants are undesirable.

Function

• Bile salt / detergent: Forms micelles that solubilize lipids, cholesterol, and lipophilic drugs in aqueous media.
• Lipid absorption: Physiologically essential for emulsification and uptake of dietary fats and fat-soluble vitamins.
• Cholagogue and choleretic activity: Stimulates bile flow and supports normal biliary function.
• Membrane permeabilization: Used in vitro to permeabilize cell membranes and study transport processes.
• Enzyme activation: Activates lipases and other bile-salt-dependent enzymes in assay systems.
• Solubilization in cell culture: Helps dissolve hydrophobic compounds in media for cell-based studies.

Source & Standardization

• Source: Synthesized from cholic acid and taurine, or isolated from bovine or ovine bile
• Production: Conjugation, salt formation, crystallization, and drying under controlled conditions
• Standardization: ≥98.0% sodium taurocholate (HPLC); identity confirmed by IR and NMR
• Forms: White to off-white crystalline powder; also available as aqueous solution on request
• 응용 분야: Pharmaceutical excipient, cell culture reagent, biochemical research, analytical standard, veterinary formulations

사양

Documentation & Supply

• Monthly capacity: 5–10 metric tons depending on grade
• 리드 타임: 3-5 business days (stock items)
• 문서: COA, MSDS, TDS, and additional regulatory support available on request
• 포장: 25 kg fiber drum with double polyethylene liner; 1 kg and 5 kg drums for pilot and laboratory use

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