Ferrous fumarate
| 제품명 | Ferrous Fumarate |
|---|---|
| CAS 번호 | 141-01-5 |
| 분자식 | C4H2FeO4 |
| 분자량 | 169.90 g/mol |
| 외관 | Reddish-orange to reddish-brown fine powder |
| Assay (Iron Content) | 31.0% – 36.0% (dried basis) |
| 건조 손실 | ≤ 1.5% |
| 중금속 | 10 ppm 이하 |
| 용해도 | Practically insoluble in water, soluble in mineral acids |
| 입자 크기 | ≥ 99% through 100 mesh (typical) |
| 패키지 | 25 kg fiber drum with double polyethylene liner |
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Synonyms: Iron(II) fumarate, Ferrous fumarate, Iron fumarate, Ferrous iron fumarate, Fumaric acid iron(II) salt, (E)-2-Butenedioic acid iron(II) salt
Ferrous fumarate has become a go-to iron source for formulators seeking a well-tolerated, high-elemental-iron alternative to ferrous sulfate. As the global demand for iron supplementation continues to rise—driven by widespread iron-deficiency anemia and growing awareness of maternal and pediatric nutrition—ferrous fumarate stands out for its favorable gastrointestinal profile and excellent stability in solid dosage forms.
Chemically, ferrous fumarate is the iron(II) salt of fumaric acid, with the formula C4H2FeO4. It is produced by reacting ferrous sulfate with sodium fumarate, yielding a reddish-orange, finely divided powder that is practically insoluble in water but readily soluble in dilute mineral acids. This low solubility contributes to its gentle effect on the stomach compared to more soluble iron salts.
Our ferrous fumarate is standardized to contain 31.0%–36.0% elemental iron, meeting the stringent requirements of the USP/EP/BP monographs. It is available in a free-flowing powder form suitable for direct compression, capsule filling, and suspension formulations. Each batch is tested for iron content, loss on drying, and heavy metals to ensure consistent performance in your finished product.
Ferrous fumarate is a coordination compound in which iron is in the +2 oxidation state, chelated by fumarate ions. The fumarate ligand not only stabilizes the ferrous ion but also contributes to the molecule’s overall stability, making it less prone to oxidation than ferrous sulfate. The compound is essentially odorless and has a slightly astringent taste.
In the body, ferrous fumarate dissociates in the acidic environment of the stomach, releasing ferrous iron for absorption in the duodenum. The fumarate moiety is metabolized via the Krebs cycle, leaving no harmful residues. This efficient delivery system allows for a high bioavailability of iron, often comparable to that of ferrous sulfate, but with a lower incidence of gastric irritation.
| 매개변수 | 사양 |
|---|---|
| Assay (Iron content) | 31.0% – 36.0% |
| 건조 손실 | ≤ 1.5% |
| 중금속 | 10 ppm 이하 |
| Arsenic | ≤ 3 ppm |
| Microbial Limits | Total aerobic count ≤ 1000 cfu/g; Yeast & Mold ≤ 100 cfu/g; E. coli absent |
| 입자 크기 | ≥ 99% through 100 mesh |