Coluracetam, a member of the racemate family of nootropic compounds, also known as MKC-231, is a nootropic compound with cognitive-enhancing and neuroprotective effects.

Coluracetam works by modulating the cholinergic system.

It is thought to increase levels of acetylcholine, a key neurotransmitter in the brain closely linked to learning and memory functions.  Coluracetam does this by increasing the number and activity of choline uptake transporters, thereby enhancing the release of acetylcholine and improving signaling between neurons.

Some early experimental and animal studies suggest that Coluracetam has potential neuroprotective and cognitive-enhancing effects.

Some other studies have found that Coluracetam has a certain improvement effect on memory impairment in AD models.

Keywords: Coluracetam CAS 135463-81-9, MKC-231, BCI-540, high-affinity choline uptake enhancer, nootropic ingredient, memory support compound, racetam family, cholinergic cognitive enhancer, research chemical, LyvBio Coluracetam

Coluracetam buy

Coluracetam is one of the few nootropics that specifically enhances high affinity choline uptake (HACU) —the rate-limiting step in acetylcholine synthesis. This mechanism directly supports cholinergic neuron function, which is critical for memory formation and cognitive processing.

Family Comparison:

CompoundCAS No.Primary MechanismRelative PotencyKey FeatureColuracetam135463-81-9HACU enhancement (unique)HighMemory consolidationPiracetam7491-74-9AMPA modulationLow (baseline)Original racetamAniracetam72432-10-1AMPA + GABAModerateAnxiolytic + cognitiveOxiracetam62613-82-5AMPA modulationModerateStimulatingPramiracetam68497-62-1AMPA + HACU (weak)HighPotent memory supportPhenylpiracetam77472-70-9AMPA + dopamineVery HighStimulating + physical

Synonyms:

• MKC-231

• BCI-540

• N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

• 1-Pyrrolidineacetamide, 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-

The cholinergic system is essential for memory formation. Age-related cognitive decline and Alzheimer’s disease are associated with reduced cholinergic function. By enhancing HACU, coluracetam supports acetylcholine production even when choline availability is limited – a unique mechanism among nootropics.

Supplier: LyvBio Co., Ltd.

LyvBio Co., Ltd. is a GMP-certified supplier of high-purity Coluracetam for research and nootropic formulation development.

Supply capabilities:

• Purity: ≥99.0% (HPLC)

• Monthly capacity: 50+ kg

• Bulk quantities: 10g – 100kg

• Lead time: 3–5 days (samples), 10–15 days (bulk)

• Documentation: COA, MSDS, HNMr, HPLC chromatogram, stability data

• Packaging: 100g, 500g, 1kg, 5kg, 10kg, 25kg

Quality assurance:

• In-house HPLC testing (≥99.0% purity)

• Heavy metals and residual solvents testing

• Stability studies (36 months)

📧 Inquiries: info@lyvbio.com

FAQs

Q: What makes Coluracetam different from other racetams?
A: Coluracetam’s primary mechanism is high-affinity choline uptake (HACU) enhancement, while most other racetams work primarily through AMPA/glutamate pathways. This makes coluracetam uniquely effective for cholinergic support and memory consolidation.

Q: Is Coluracetam a dietary supplement?
A: Coluracetam is not approved as a dietary supplement in most markets (including the USA and EU). It is sold as a research chemical or nootropic ingredient. Regulatory status varies by country. Buyers must verify local compliance.

Q: Does Coluracetam require a choline source?
A: Not strictly, but co-administration with a choline source (alpha-GPC, CDP-choline, or lecithin) may enhance its effects by providing substrate for acetylcholine synthesis. This is a common practice in nootropic stacks.

Q: What is the half-life of Coluracetam?
A: Approximately 2–3 hours in animal studies. Human pharmacokinetics are not well-characterized.

Q: Can Coluracetam be taken sublingually?
A: Yes, but the taste is very bitter. Sublingual administration may provide faster absorption, though bioavailability data are limited.

📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com