D-Biotin

Synonyms: Vitamin B7, Vitamin H, Coenzyme R, Biotin, cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid

D-Biotin is a water-soluble B-complex vitamin that functions as a covalently bound cofactor for carboxylase enzymes. Its structure features a tetrahydroimidizalone ring fused with a tetrahydrothiophene ring bearing a valeric acid side chain, enabling ATP-dependent activation and attachment to carboxylase apoenzymes. This unique architecture allows biotin to shuttle activated carboxyl groups in essential metabolic pathways, including gluconeogenesis, fatty acid synthesis, and amino acid catabolism.

While biotin occurs naturally in foods such as eggs, nuts, and legumes, commercial D-Biotin is produced through multi-step chemical synthesis. LyvBio supplies high-purity D-Biotin conforming to USP/EP standards, with assay typically ≥98.5% by HPLC. Our product is a white crystalline powder, practically odorless, and is available in various particle sizes to suit different formulation needs.

D-Biotin is widely used in pharmaceutical preparations, dietary supplements, and cosmetic products. In the pharmaceutical industry, it is included in multivitamin injections and oral formulations for the prevention and treatment of biotin deficiency. In personal care, it is a key ingredient in hair and nail care products due to its role in keratin infrastructure. Additionally, biotin is employed as a research reagent in biochemical assays, particularly in biotinylation and affinity purification techniques.

化学構造と性質

D-Biotin (C10H16N2O3S) has a molecular weight of 244.31 g/mol. It is a white to off-white crystalline powder, slightly soluble in water (about 0.2 mg/mL at 25°C) and soluble in ethanol. The molecule contains a ureido ring (imidazolidone) fused to a tetrahydrothiophene ring, with a valeric acid side chain. The carboxylic acid group is essential for its biological activity, allowing conjugation to enzymes and proteins. Biotin is stable under normal storage conditions but should be protected from light and moisture.

作用機序

• Carboxylase cofactor: Biotin is covalently attached to the epsilon-amino group of a lysine residue in carboxylase enzymes, facilitating the transfer of activated carboxyl groups from bicarbonate to substrates.
• Gluconeogenesis: As a cofactor for pyruvate carboxylase, biotin is crucial for converting pyruvate to oxaloacetate, a key step in glucose production.
• Fatty acid synthesis: Acetyl-CoA carboxylase requires biotin for the conversion of acetyl-CoA to malonyl-CoA, the committed step in fatty acid biosynthesis.
• Amino acid metabolism: Biotin-dependent enzymes such as propionyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase are involved in the catabolism of certain amino acids.
• Gene regulation: Biotin affects gene expression through biotinylation of histones and modulation of transcription factors, influencing cell signaling and proliferation.

品質仕様

供給および書類

• 容量: 50 metric tons per year
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS, USP/EP compliance statements
• パッケージ: 25 kg fiber drum with double polyethylene liners; custom packaging available upon request

見積依頼

• リブバイオ株式会社. — メールアドレス： info@lyvbio.com