9-Me-BC

Synonyms: 9-Methyl-β-carboline, 9-Me-BC, 9-Methyl-9H-pyrido[3,4-b]indole, 9-Methylnorharman, 9-Methyl-β-carboline

9-Me-BC is a synthetic methylated β-carboline derivative that has become a molecule of interest in neuropharmacology and medicinal chemistry research. Unlike many β-carbolines isolated from natural sources, 9-Me-BC is produced through controlled chemical synthesis, allowing for high purity and consistent supply. Its structure features a methyl group at the indole nitrogen, a modification that significantly influences its interaction with monoamine systems and its metabolic stability compared to norharman and harman.

In the research community, 9-Me-BC is primarily investigated for its potential effects on dopaminergic neurons and neurotrophic signaling. Preclinical studies suggest it may upregulate tyrosine hydroxylase and promote neurite outgrowth, making it a valuable tool for studying Parkinson’s disease models and dopamine-related pathways. Its ability to cross the blood-brain barrier and its relatively favorable pharmacokinetic profile in animal models have further fueled interest.

While not approved for human use, 9-Me-BC is supplied as a reference standard and research chemical for in vitro and in vivo studies. It is available at high purity, typically ≥98% by HPLC, and is characterized by NMR and mass spectrometry to ensure structural integrity. Researchers value it for its selectivity and the reproducibility it brings to neurobiological experiments.

機能

• Dopaminergic modulation: May enhance tyrosine hydroxylase expression and dopamine synthesis in neuronal cultures.
• Neurotrophic support: Promotes neurite outgrowth and survival in dopaminergic cell models.
• MAO inhibition: Exhibits inhibitory activity against monoamine oxidase, contributing to its neuroactive profile.
• 認知機能の向上: Investigated for potential pro-cognitive effects in animal studies.
• 神経保護: Shows antioxidant and anti-inflammatory properties in preclinical models.

Source & Standardization

• 出典: Synthetic chemical synthesis
• Standardization: ≥98.0% (HPLC)
• 識別: NMR, MS, IR
• Forms: Crystalline powder
• 用途: Research on Parkinson’s disease, dopamine regulation, neuroprotection, and cognitive function

仕様

資料・供給

• 月間処理能力: 5–10 kg
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS, NMR, HPLC
• パッケージ: 1 kg, 5 kg, 25 kg fiber drums with inner liners

見積依頼

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