パルミトイルトリペプチド-38

同義語： Palmitoyl Tripeptide-38, N-Palmitoyl Tripeptide-38, Palmitoyl Tripeptide-38 Acetate, C16-Tripeptide-38

Palmitoyl Tripeptide-38 is a synthetic lipopeptide that combines a short peptide sequence with a palmitic acid (C16) tail. The peptide portion, typically composed of three amino acids, is designed to mimic a fragment of the laminin-5 protein, which plays a critical role in dermal-epidermal junction (DEJ) integrity. The palmitoyl chain enhances lipophilicity, facilitating penetration through the stratum corneum and improving bioavailability in skin tissue.

This molecule is produced via solid-phase peptide synthesis (SPPS), followed by N-terminal palmitoylation. It is commercially available as a white to off-white powder with high purity (≥95% by HPLC). Palmitoyl Tripeptide-38 is a key active ingredient in advanced anti-aging and skin-repair formulations, often incorporated into serums, creams, and essences targeting wrinkle reduction and skin firmness.

Research indicates that Palmitoyl Tripeptide-38 stimulates the synthesis of key extracellular matrix (ECM) components, including collagen I, III, IV, fibronectin, and hyaluronic acid, by activating the laminin-5 pathway. This makes it a valuable peptide for cosmetic and pharmaceutical applications aimed at restoring skin structure and combating chronological and photoaging.

化学構造と性質

Palmitoyl Tripeptide-38 is characterized by a tripeptide sequence (e.g., palmitoyl-Lys-Val-Lys) linked to palmitic acid via an amide bond. The molecular formula is C₃₃H₆₂N₆O₆ with a molecular weight of 662.9 g/mol. The lipophilic palmitoyl group enhances skin penetration, while the hydrophilic peptide moiety interacts with cellular targets. It is soluble in water, ethanol, and hydroglycolic solutions, and should be stored under cool, dry conditions to maintain stability.

作用機序

• Laminin-5 stimulation: Palmitoyl Tripeptide-38 upregulates laminin-5, a key protein in the dermal-epidermal junction, promoting structural cohesion.
• ECM component synthesis: It boosts collagen I, III, IV, fibronectin, and hyaluronic acid production, improving skin density and elasticity.
• しわの改善: By reinforcing the DEJ and ECM, it visibly reduces wrinkle depth and improves skin smoothness.
• Skin repair: Accelerates recovery processes, making it suitable for post-procedure and sensitive skin care.

品質仕様

供給および書類

• 容量: 10 kg per month
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS available upon request
• パッケージ: 1 g, 10 g, 100 g in amber glass vials, or customized packaging

見積依頼

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