Veratridine

Sinonimi: 3-Veratroylveracevine, Veratridine, (3β,4α,16β)-4,9-Epoxycevane-3,4,12,14,16,17,20-heptol 3-(3,4-dimethoxybenzoate), Cevane-3,4,12,14,16,17,20-heptol 3-(3,4-dimethoxybenzoate)

Veratridine is a steroidal alkaloid derived from the cevane skeleton, featuring a 3,4-dimethoxybenzoyl ester at the C3 position. This lipophilic moiety enhances its interaction with voltage-gated sodium channels, making it a valuable tool in neuropharmacology. The compound is isolated from plants of the genus Veratrum, such as Veratrum album e Veratrum viride, and is known for its potent effects on ion channel dynamics.

As a research-grade chemical, Veratridine is typically available at ≥98% purity (HPLC). It is widely used in electrophysiology and cell-based assays to study sodium channel function, neurotoxicity, and cardiac arrhythmias. Its ability to lock sodium channels in the open state provides a unique mechanism for investigating excitability and signal transduction.

Beyond basic research, Veratridine serves as a reference standard in analytical method development and as a precursor in the synthesis of derivatives for drug discovery. Its commercial relevance spans pharmaceutical R&D, toxicology, and biochemical reagent supply.

Chemical Structure & Properties

Veratridine belongs to the veratrum alkaloids, characterized by a complex polycyclic cevane framework with multiple hydroxyl groups. The molecule’s amphiphilic nature—combining a polar polyhydroxy core with a nonpolar aromatic ester—facilitates membrane permeability and receptor binding. It is stable under recommended storage conditions but should be protected from light and moisture to prevent hydrolysis of the ester bond.

Meccanismo d'azione

• Sodium channel activation: Binds to neurotoxin receptor site 2 on voltage-gated sodium channels, delaying inactivation and causing persistent depolarization.
• Neurotransmitter release: Induces calcium influx and subsequent release of neurotransmitters in synaptosomes.
• Cardiotoxicity: Prolongs action potential duration in cardiac myocytes, leading to arrhythmogenic effects.
• Excitotoxicity: Excessive sodium influx triggers glutamate release and neuronal damage in vitro.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: Up to 100 g per batch
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS available upon request
• Confezionamento: Amber glass vials under argon, sealed and light-protected

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our standard MOQ is 10 mg. Larger quantities can be accommodated for bulk orders.

How long does delivery take?

For stock items, delivery is typically 3-5 business days from order confirmation.

Can you provide a COA and sample?

Yes, a COA is included with every shipment. Samples (typically 10-20 mg) are available for evaluation upon request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.