Hemin

Synonyms: Hemin chloride, Chloro(protoporphyrinato)iron(III), Chlorohemin, Ferriprotoporphyrin IX chloride, Hemin (bovine), Protohemin

In the evolving landscape of biopharmaceutical and diagnostic research, hemin has emerged as a molecule of significant interest. Its unique ability to modulate heme-dependent biological pathways has positioned it as a critical raw material for the development of novel therapeutics, particularly in the fields of hematology, oncology, and infectious diseases. As the demand for reliable and high-purity heme compounds grows, hemin stands out for its versatility and essential role in advanced life science applications.

Hemin, also known as chlorohemin, is a porphyrin complex containing iron in the +3 oxidation state, with a chloride ligand. It is the oxidized form of heme, the prosthetic group of hemoglobin, myoglobin, and various heme enzymes. Commercially, hemin is typically produced through controlled chemical synthesis from protoporphyrin IX or extracted from bovine blood, followed by purification steps to achieve high purity.

Our hemin is standardized to ≥98% purity (HPLC), ensuring consistent performance in sensitive applications. It is a dark brown to black crystalline powder, insoluble in water but soluble in aqueous alkali. Each batch is rigorously tested to meet stringent quality standards, making it suitable for use as a reference standard, in cell culture, and as a key intermediate in pharmaceutical synthesis.

Présentation et composition du produit

Hemin is a coordination complex consisting of a protoporphyrin IX ring with a central iron(III) ion and a chloride ligand. Its molecular formula is C₃₄H₃₂ClFeN₄O₄, and it has a molecular weight of 651.94 g/mol. The molecule is characterized by its intense absorption in the visible spectrum, which makes it useful in spectrophotometric assays.

As a stable, crystalline form of heme, hemin is often used as a source of iron and porphyrin in biological systems. It plays a crucial role in various biochemical processes, including oxygen transport, electron transfer, and gene regulation. Its ability to intercalate into membranes and interact with proteins makes it a valuable tool in research and development.

Principales applications

• Pharmaceutical intermediates: Used in the synthesis of heme-based drugs and as a precursor for other porphyrin derivatives.
• Diagnostic reagents: Employed in clinical chemistry for the determination of hemoglobin and as a standard in quality control.
• Cell culture: Supplemented in culture media to support the growth of fastidious organisms and cells requiring heme.
• Recherche: Utilized in studies of heme oxygenase, nitric oxide synthase, and other heme-containing enzymes.
• Food and feed: As a source of iron in nutritional supplements and animal feed additives.

Qualité et normes

Emballage et approvisionnement

• Emballage: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums, with desiccant.
• Quantité minimale de commande: 1 kg
• Délai de livraison: 3 à 5 jours ouvrés (articles en stock)
• Documentation: COA, MSDS, TDS available upon request.

Demande de devis

• LyvBio Co. — E-mail : info@lyvbio.com