Cooling Agent WS-12

Synonymes : N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]acetamide, WS-12, Cooling Agent 12, Menthyl acetamide, N-[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]acetamide, Acetamide, N-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]-

Cooling Agent WS-12 has become a go-to ingredient for formulators seeking a long-lasting, clean cooling sensation without the sharp bite of menthol. Its popularity spans oral care, confectionery, and topical analgesics, where a smooth, sustained effect is prized. Unlike traditional cooling agents, WS-12 delivers a gradual onset and extended duration, making it ideal for products where a lingering freshness is desired. The compound is particularly valued in applications where menthol’s volatility and odor would be detrimental, such as in premium toothpastes, mouthwashes, and cosmetic creams.

Chemically, WS-12 is a cyclohexyl acetamide derivative, structurally related to other well-known coolants like WS-3 and WS-23. It is synthesized through a multi-step process starting from menthol, resulting in a high-purity white crystalline solid. The molecule interacts with the TRPM8 receptor, the same cold-sensing channel activated by menthol, but with a higher selectivity and lower irritation potential. This makes it suitable for products targeting sensitive mucous membranes or skin.

LyvBio supplies WS-12 with a minimum assay of 99.0% (HPLC), ensuring consistent performance in your formulations. Our material is manufactured under strict quality control and is available in bulk quantities to meet your production needs. Whether you are developing a new cooling product or reformulating an existing one, WS-12 offers a reliable, high-impact cooling solution.

Présentation et composition du produit

WS-12 belongs to the class of N-substituted cyclohexyl carboxamides, a family of synthetic coolants that also includes WS-3 and WS-5. Its structure features a menthyl-like cyclohexane ring with an acetamide group, which confers a unique cooling profile. The compound is essentially odorless and tasteless at typical use levels, blending seamlessly into flavor and fragrance systems.

Because it is not volatile, WS-12 remains active on the skin or mucosa for extended periods, unlike menthol which evaporates quickly. This property is especially beneficial in leave-on products like lip balms, pain-relief gels, and insect repellents. The molecule is stable under normal storage conditions and compatible with a wide range of cosmetic and pharmaceutical excipients.

Principales applications

• Oral Care: Provides a long-lasting cooling effect in toothpastes, mouthwashes, and chewing gums, often at concentrations of 0.05–0.2%.
• Confectionery: Used in candies, mints, and chocolates to deliver a refreshing sensation without the sharpness of menthol.
• Topical Analgesics: Incorporated into creams and gels for muscle pain, arthritis, and minor injuries, offering a soothing coolness that helps distract from pain.
• Cosmetics & Personal Care: Added to aftershaves, shaving creams, and skincare products for a refreshing feel and improved sensory profile.
• Pharmaceuticals: Employed in throat lozenges, cough drops, and nasal sprays to provide symptomatic relief and improve palatability.

Qualité et normes

Emballage et approvisionnement

• Emballage: 25 kg net weight in fiber drums with double polyethylene liners. Custom packaging available upon request.
• Quantité minimale de commande: 1 kg for sample orders; 25 kg for bulk orders.
• Délai de livraison: 3 à 5 jours ouvrés (articles en stock)
• Documentation: COA, MSDS, TDS, and nutritional information available. Additional documentation for regulatory compliance can be provided.

Demande de devis

• LyvBio Co. — E-mail : info@lyvbio.com