| Product Name | Nicotinamide Riboside Chloride |
| Other Names | NR Chloride; Niacinamide Riboside Chloride; Nicotinamide Riboside (NR) |
| CAS Number | 23111-00-4 |
| Molecular Formula | C₁₁H₁₅ClN₂O₅ |
| Molecular Weight | 290.70 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥ 98.0% (≥99.0% pharmaceutical grade) |
| Loss on Drying | ≤ 1.0% |
| pH (1% solution) | 3.0–5.0 |
| Heavy Metals | Pb ≤ 1 ppm; As ≤ 1 ppm; Cd ≤ 1 ppm; Hg ≤ 0.1 ppm |
| Residual Solvents | Meet USP <467> |
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Nicotinamide Riboside (NR) Chloride is a pyridine-nucleoside form of vitamin B3 and a direct precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme found in every living cell. NAD+ plays a critical role in cellular energy metabolism, DNA repair, gene expression (via sirtuins), and cellular stress resistance.
Nicotinamide Riboside is one of the most efficient and clinically studied NAD+ precursors available. Unlike nicotinamide (niacinamide) or nicotinic acid, NR is preferentially converted to NAD+ through a distinct biosynthetic pathway (the Preiss-Handler pathway) with lower risk of side effects (flushing, hepatotoxicity at high doses). NR chloride is the most common commercially available salt form due to its stability and bioavailability.
NAD+ levels decline naturally with age (by 30–50% by middle age), contributing to metabolic dysfunction, cognitive decline, muscle weakness, and increased susceptibility to age-related diseases. NAD+ precursors like Nicotinamide Riboside have become a cornerstone of the healthy aging and longevity supplement market, projected to grow at a CAGR of 15–20% through 2030.
| Application | Typical Dosage | Key Claims |
|---|---|---|
| Cellular health / NAD+ restoration | 300–600 mg/day | Supports healthy aging, cellular energy |
| Longevity support | 300–500 mg/day | Activates sirtuins, DNA repair |
| Anti-aging formula | 300–600 mg/day | Mitochondrial support, oxidative stress reduction |
| Application | Typical Dosage | Clinical Evidence |
|---|---|---|
| Cellular energy / ATP support | 300–600 mg/day | Reduces fatigue, supports mitochondrial function |
| Metabolic health | 500–1,000 mg/day | Supports healthy glucose and lipid metabolism (clinical trials) |
| Weight management (supportive) | 500 mg/day | Supports metabolic rate (indirect) |
| Application | Typical Dosage | Mechanism |
|---|---|---|
| Brain health / cognitive function | 300–600 mg/day | Supports neuronal NAD+ levels, neuroprotection |
| Neuroprotection (aging) | 500 mg/day | Reduces oxidative stress in brain tissue (preclinical) |
| Application | Typical Dosage | Evidence Base |
|---|---|---|
| Muscle endurance & recovery | 500–1,000 mg/day | Clinical trials show improved muscle function in aging adults |
| Exercise performance | 500 mg pre-workout | Supports NAD+ during high-intensity exercise |
| Muscle preservation (sarcopenia) | 500–1,000 mg/day | Supports muscle mitochondrial health (aging population) |
LyvBio Co., Ltd. is a supplier of high-purity Nicotinamide Riboside Chloride for the nutraceutical, healthy aging, and sports nutrition industries.
Supply capabilities:
Purity: ≥98.0% (standard), ≥99.0% (pharmaceutical grade)
Form: Crystalline powder (chloride salt)
Monthly capacity: 500+ kg
Bulk quantities: 100g – 5,000kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS, TDS, HPLC chromatogram, stability data, allergen statement, Non-GMO
Q: What is the difference between Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)?
A: Both are NAD+ precursors. NR is converted to NMN by NRK enzymes, then NMN is converted to NAD+ by NMNAT enzymes. NMN requires one less enzymatic step. However, NR chloride is FDA GRAS for dietary supplements, while NMN is currently not lawful as a dietary supplement in the USA (FDA determination). NR also has more extensive human clinical data.
Q: Is Nicotinamide Riboside Chloride the same as Niacin or Niacinamide?
A: No. NR is a distinct vitamin B3 derivative (a pyridine-nucleoside). Niacin (nicotinic acid) causes flushing; niacinamide (nicotinamide) does not elevate NAD+ efficiently due to NAMPT rate limitation. NR is specifically designed for NAD+ elevation.
Q: What is the recommended dosage for NAD+ restoration?
A: Clinical studies typically use 250–1,000 mg/day. Most studies show significant NAD+ elevation at 500 mg/day. For general wellness, 250–300 mg/day is sufficient.
Q: How long does it take to see NAD+ elevation?
A: Human studies show significant NAD+ elevation in blood within 2 weeks of daily NR supplementation. Tissue NAD+ levels may take longer (4–8 weeks).
Q: Is NR chloride stable in gummy formulations?
A: Challenging but possible. NR is heat-sensitive (degrades >80°C) and light-sensitive. Gummy processing must be low-temperature, and packaging must be opaque. Most manufacturers prefer capsules or powders for NR.
Q: Is NR chloride vegan?
A: Yes. NR chloride is synthetically produced, not derived from animal sources. LyvBio NR chloride is 100% vegan.
Q: What is your MOQ?
A: Sample orders: 100g–1kg. Trial production: 5–25 kg. Commercial: Negotiable (100kg+ receives volume pricing). Lead time: 3–5 days (samples); 10–15 days (bulk).
Ready to formulate with the most clinically studied NAD+ precursor for healthy aging and cellular energy?
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
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