| 製品名 | Nicotinamide Riboside Chloride |
| 別名 | NR Chloride; Niacinamide Riboside Chloride; Nicotinamide Riboside (NR) |
| CAS番号 | 23111-00-4 |
| 分子式 | C₁₁H₁₅ClN₂O₅ |
| 分子量 | 290.70 g/mol |
| 外観 | 白色からオフホワイトの結晶性粉末 |
| 純度（HPLC） | ≥ 98.0% (≥99.0% pharmaceutical grade) |
| 乾燥減量 | ≤ 1.0% |
| pH（1%溶液） | 3.0–5.0 |
| 重金属 | Pb ≤ 1 ppm; As ≤ 1 ppm; Cd ≤ 1 ppm; Hg ≤ 0.1 ppm |
| 残留溶剤 | USP について |
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Nicotinamide Riboside (NR) Chloride is a pyridine-nucleoside form of vitamin B3 and a direct precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme found in every living cell. NAD+ plays a critical role in cellular energy metabolism, DNA repair, gene expression (via sirtuins), and cellular stress resistance.
Nicotinamide Riboside is one of the most efficient and clinically studied NAD+ precursors available. Unlike nicotinamide (niacinamide) or nicotinic acid, NR is preferentially converted to NAD+ through a distinct biosynthetic pathway (the Preiss-Handler pathway) with lower risk of side effects (flushing, hepatotoxicity at high doses). NR chloride is the most common commercially available salt form due to its stability and bioavailability.
NAD+ levels decline naturally with age (by 30–50% by middle age), contributing to metabolic dysfunction, cognitive decline, muscle weakness, and increased susceptibility to age-related diseases. NAD+ precursors like Nicotinamide Riboside have become a cornerstone of the healthy aging そして longevity supplement market, projected to grow at a CAGR of 15–20% through 2030.
| 用途 | 一般的な用量 | 主な主張 |
|---|---|---|
| Cellular health / NAD+ restoration | 1日あたり300～600 mg | Supports healthy aging, cellular energy |
| Longevity support | 1日あたり300～500 mg | Activates sirtuins, DNA repair |
| Anti-aging formula | 1日あたり300～600 mg | Mitochondrial support, oxidative stress reduction |
| 用途 | 一般的な用量 | 臨床的根拠 |
|---|---|---|
| Cellular energy / ATP support | 1日あたり300～600 mg | Reduces fatigue, supports mitochondrial function |
| Metabolic health | 500–1,000 mg/day | Supports healthy glucose and lipid metabolism (clinical trials) |
| Weight management (supportive) | 500 mg/day | Supports metabolic rate (indirect) |
| 用途 | 一般的な用量 | 仕組み |
|---|---|---|
| Brain health / cognitive function | 1日あたり300～600 mg | Supports neuronal NAD+ levels, neuroprotection |
| Neuroprotection (aging) | 500 mg/day | Reduces oxidative stress in brain tissue (preclinical) |
| 用途 | 一般的な用量 | エビデンスベース |
|---|---|---|
| Muscle endurance & recovery | 500–1,000 mg/day | Clinical trials show improved muscle function in aging adults |
| Exercise performance | 500 mg pre-workout | Supports NAD+ during high-intensity exercise |
| Muscle preservation (sarcopenia) | 500–1,000 mg/day | Supports muscle mitochondrial health (aging population) |
リブバイオ株式会社. is a supplier of high-purity Nicotinamide Riboside Chloride for the nutraceutical, healthy aging, and sports nutrition industries.
供給能力：
純度： ≥98.0%（標準品）、≥99.0%（医薬品グレード）
フォーム： Crystalline powder (chloride salt)
月間処理能力： 500kg以上
大量注文： 100g ～ 5,000kg
リードタイム： 3～5日（サンプル）、10～15日（大量注文）
ドキュメント： COA、MSDS、TDS、HPLCクロマトグラム、安定性データ、アレルゲン表示、非遺伝子組み換え
Q: What is the difference between Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)?
A: Both are NAD+ precursors. NR is converted to NMN by NRK enzymes, then NMN is converted to NAD+ by NMNAT enzymes. NMN requires one less enzymatic step. However, NR chloride is FDA GRAS for dietary supplements, while NMN is currently not lawful as a dietary supplement in the USA (FDA determination). NR also has more extensive human clinical data.
Q: Is Nicotinamide Riboside Chloride the same as Niacin or Niacinamide?
A: No. NR is a distinct vitamin B3 derivative (a pyridine-nucleoside). Niacin (nicotinic acid) causes flushing; niacinamide (nicotinamide) does not elevate NAD+ efficiently due to NAMPT rate limitation. NR is specifically designed for NAD+ elevation.
Q: What is the recommended dosage for NAD+ restoration?
A: Clinical studies typically use 250–1,000 mg/day. Most studies show significant NAD+ elevation at 500 mg/day. For general wellness, 250–300 mg/day is sufficient.
Q: How long does it take to see NAD+ elevation?
A: Human studies show significant NAD+ elevation in blood within 2 weeks of daily NR supplementation. Tissue NAD+ levels may take longer (4–8 weeks).
Q: Is NR chloride stable in gummy formulations?
A: Challenging but possible. NR is heat-sensitive (degrades >80°C) and light-sensitive. Gummy processing must be low-temperature, and packaging must be opaque. Most manufacturers prefer capsules or powders for NR.
Q: Is NR chloride vegan?
A: Yes. NR chloride is synthetically produced, not derived from animal sources. LyvBio NR chloride is 100% vegan.
Q: 最小注文数量（MOQ）はどれくらいですか？
A: サンプル注文：100g～500g。試作：1～5kg。量産：要相談（25kg以上は数量割引が適用されます）。納期：3～5日（サンプル）、10～15日（量産）。.
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