Mangosteen Extract-Mangostin

Sinónimos: Mangostin, α-Mangostin, Alpha-Mangostin, Mangosteen Extract, Garcinia mangostana Extract, Mangosteen Pericarp Extract, 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one, Mangosteen Xanthone

Mangostin (α-Mangostin) is the primary bioactive xanthone isolated from the pericarp (rind) of the mangosteen fruit (Garcinia mangostana L.), a tropical fruit native to Southeast Asia. Mangosteen has been used traditionally in folk medicine for centuries to treat skin infections, wounds, diarrhea, and inflammatory conditions.

α-Mangostin is one of the most extensively studied xanthones, recognized for its potent antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Its molecular structure features a xanthone core with multiple hydroxyl and prenyl groups, which contribute to its ability to scavenge free radicals, modulate inflammatory pathways, and interact with cellular signaling molecules.

Mangostin is widely used in dietary supplements, functional foods, and cosmetic formulations targeting antioxidant support, inflammatory conditions, and skin health. It is also a subject of extensive pharmacological research, particularly in the fields of oncology, metabolic health, and neuroprotection.

Función

• Antioxidant activity: Scavenges free radicals, upregulates endogenous antioxidant enzymes.

• Anti-inflammatory activity: Inhibits COX-2, LOX, and NF-κB signaling pathways.

• Antimicrobial activity: Exhibits broad-spectrum activity against bacteria, fungi, and viruses.

• Anticancer activity: Induces apoptosis and inhibits proliferation in cancer cell lines (research).

• Metabolic support: Supports healthy lipid and glucose metabolism.

• Skin health: Protects against UV-induced damage, supports collagen synthesis.

Source & Standardization Grades

• Source: Pericarp of Garcinia mangostana L. (mangosteen)

• Extraction: Ethanol or ethyl acetate extraction, followed by purification

• Standardization: α-Mangostin (HPLC)