Taurochenodeoxycholsäure

Synonyme: Taurochenodeoxycholic acid, TCDCA, 2-[(3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl]aminoethanesulfonic acid, Chenodeoxycholyltaurine, Taurochenodeoxycholate

Taurochenodeoxycholic acid (TCDCA) is a taurine-conjugated bile acid that occurs naturally in the bile of humans and other mammals. It is one of the primary bile salts, synthesized in the liver from chenodeoxycholic acid and taurine. This conjugation significantly increases its water solubility and reduces its cytotoxicity compared to unconjugated bile acids. TCDCA plays a critical role in lipid digestion and absorption, and has emerged as a molecule of interest in pharmaceutical and metabolic research.

As a bile acid derivative, TCDCA is structurally characterized by a steroid nucleus with hydroxyl groups at the 3α and 7α positions, and a side chain ending in a taurine moiety. This amphipathic structure allows it to act as a detergent, forming mixed micelles that facilitate the emulsification of dietary fats and fat-soluble vitamins. Its physiological importance extends beyond digestion; TCDCA is a signaling molecule that activates nuclear receptors such as FXR and TGR5, influencing glucose and lipid metabolism, energy homeostasis, and inflammation.

In the pharmaceutical industry, TCDCA is used as an intermediate in the synthesis of ursodeoxycholic acid (UDCA) and other bile acid-based drugs. It also serves as a reference standard for analytical methods and as a research tool in studies of bile acid metabolism, cholestasis, and liver diseases. Additionally, TCDCA has shown potential in drug delivery systems, particularly for enhancing the oral bioavailability of poorly soluble drugs through micellar solubilization.

LyvBio supplies high-purity Taurochenodeoxycholic acid with consistent quality, supported by comprehensive documentation. Our product is manufactured under strict quality control and is suitable for use as an API intermediate, reference standard, and research chemical.

Funktion

• Lipid digestion and absorption: TCDCA acts as a detergent, emulsifying dietary fats and forming mixed micelles to facilitate their absorption in the intestine.
• Signaling molecule: Activates FXR and TGR5 receptors, regulating bile acid synthesis, glucose homeostasis, and energy expenditure.
• Cholestasis treatment: Used in studies for its ability to modulate bile flow and protect against cholestatic liver injury.
• Drug delivery enhancer: Improves the solubility and permeability of poorly water-soluble drugs.
• Reference standard: Serves as a calibration standard for HPLC and LC-MS analysis of bile acids in biological samples.

Source & Standardization

• Quelle: Synthetic or semi-synthetic from chenodeoxycholic acid
• Extraction: Chemical conjugation of chenodeoxycholic acid with taurine, followed by purification
• Standardization: ≥98.0% (HPLC)
• Forms: White to off-white crystalline powder
• Anwendungen: Pharmaceutical intermediates, reference standards, research on bile acid metabolism, drug delivery systems

Technische Daten

Documentation & Supply

• Monthly capacity: 500 kg
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS available upon request
• Verpackung: 1 kg aluminum foil bag, 25 kg fiber drum with double PE liner

Angebotsanfrage

• LyvBio GmbH. — E-Mail: info@lyvbio.com