Acacetin

Synonyms: 5,7-Dihydroxy-4′-methoxyflavone, 4′-Methylapigenin, Apigenin 4′-methyl ether, Acacetin

Acacetin has been drawing steady attention from formulation scientists and procurement teams alike, largely because it sits at the intersection of two strong trends: the push for multi-target flavonoid actives and the demand for well-characterized, scalable botanical compounds. You’ll find it specified in products ranging from sleep and mood support to metabolic and skin-health formulations, where its flavone backbone offers a distinct profile compared to more common flavonols like quercetin or kaempferol.

Chemically, acacetin is the 4′-methyl ether of apigenin, a flavone aglycone widely distributed in the plant kingdom. It was first isolated from Acacia farnesiana and later identified in a range of species including Chrysanthemum morifolium, Robinia pseudoacacia, and various Lamiaceae herbs. Commercial material is typically obtained either through extraction from botanical sources followed by purification, or by semi-synthetic methylation of apigenin—both routes yielding the same crystalline compound.

Our acacetin is supplied as a high-purity crystalline powder, standardized to ≥98.0% by HPLC, with tight control on residual solvents and heavy metals. It is designed for researchers and formulators who need a reliable, reproducible flavone reference standard or a functional active for advanced development work.

Product Overview & Composition

Acacetin belongs to the flavone subclass of flavonoids, characterized by a 2-phenylchromen-4-one skeleton. Its substitution pattern—hydroxyl groups at C5 and C7 and a methoxy group at C4’—gives it a more lipophilic character than apigenin, which often translates into different membrane permeability and metabolic stability in vitro. The compound is a single, well-defined entity, not a mixture, and is routinely characterized by HPLC, NMR, and MS for identity confirmation.

Because it is a pure compound rather than an extract, batch-to-batch consistency is high. The material is typically produced under controlled conditions to minimize oxidation and ensure a stable, free-flowing powder. It is compatible with common organic solvents used in formulation and analytical workflows.

Key Applications

• Nutraceutical and dietary supplement formulations: Used as a standalone active or in combination with other flavonoids for sleep, relaxation, and antioxidant support products.
• Pharmaceutical research: Investigated for anti-inflammatory, neuroprotective, and metabolic effects in preclinical models; serves as a tool compound for studying flavone pharmacology.
• Cosmeceuticals and skin care: Incorporated into anti-aging and soothing formulations for its antioxidant and potential anti-tyrosinase activity.
• Analytical reference standard: Employed in HPLC and LC-MS methods for identification and quantification of acacetin in plant extracts and biological matrices.
• Flavor and fragrance research: Studied as a minor constituent in certain essential oils and plant volatiles, though not typically used as a flavoring itself.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg fiber drum with double polyethylene liner; smaller quantities available in amber glass bottles or foil bags.
• MOQ: 1 kg for standard packs; custom quantities upon request.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and if required, method validation reports and residual solvent statements.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com