Spermidine

Spermidine is a naturally occurring polyamine compound found in all living organisms, playing an essential role in cellular growth, proliferation, and differentiation.

It is synthesized endogenously from putrescine via the addition of an aminopropyl group derived from decarboxylated S-adenosylmethionine (SAM).

Dietary sources include wheat germ, soybeans, aged cheese, mushrooms, and certain fruits.

• Autophagy induction: Potent activator of autophagic flux, promoting cellular clearance and renewal.

• DNA/chromatin stabilization: Binds to nucleic acids, protecting against oxidative damage and maintaining chromatin conformation.

• Cellular proliferation: Essential polyamine for cell cycle progression and tissue regeneration.

• Anti-inflammatory potential: Modulates inflammatory signaling pathways.

• Neuroprotection: Supports neuronal survival and function via autophagy and anti-apoptotic mechanisms.

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