Praziquantel

Từ đồng nghĩa: Biltricide, Droncit, Pyquiton, Cesol, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Praziquantel is a synthetic pyrazinoisoquinoline anthelmintic that has become the gold standard for treating schistosomiasis and a broad range of trematode and cestode infections in both human and veterinary medicine. Since its introduction in the 1970s, it has been listed on the WHO Model List of Essential Medicines and remains the only drug routinely used in mass drug administration programs against schistosomiasis worldwide.

Its anthelmintic action arises from a rapid, calcium-dependent contraction of the parasite musculature, followed by tegumental damage that exposes the worm to host immune attack. The compound is a racemic mixture of two enantiomers; the (R)-enantiomer carries the primary activity, while the (S)-enantiomer contributes little to efficacy but influences taste and formulation properties.

LyvBio supplies praziquantel as a high-purity, white to off-white crystalline powder with an assay of ≥98.0% by HPLC. It is routinely used in pharmaceutical manufacturing, veterinary formulations, and research settings where consistent particle size and low impurity profiles are critical for reproducible tableting and suspension stability.

Function & Mechanism

• Antischistosomal activity: Rapidly induces tetanic contraction and tegumental disruption in Schistosoma species, leading to parasite death.
• Anticestodal activity: Effective against tapeworms such as Taenia solium, Taenia saginata, and Hymenolepis nana by impairing worm attachment and survival.
• Antitrematodal activity: Active against liver flukes (Clonorchis sinensis, Opisthorchis viverrini) and lung flukes (Paragonimus species).
• Calcium influx modulation: Increases calcium permeability in parasite membranes, causing irreversible muscular contraction.
• Immune-mediated clearance: Disrupted tegument exposes parasite antigens, enhancing host immune recognition and elimination.

Nguồn gốc và tiêu chuẩn hóa

• Nguồn: Synthetic chemical, not derived from botanical or animal sources.
• Synthesis: Produced via multi-step organic synthesis from cyclohexanecarboxylic acid and phenethylamine derivatives, followed by cyclization and purification.
• Tiêu chuẩn hóa: ≥98.0% praziquantel by HPLC; enantiomeric ratio and impurity profile controlled per EP/USP monographs.
• Forms: White to off-white crystalline powder, suitable for direct compression or suspension formulations.
• Ứng dụng: Human and veterinary anthelmintic tablets, oral suspensions, and research on helminth biology.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Công suất hàng tháng: 5 metric tons
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS, and stability data available upon request
• Bao bì: 25 kg fiber drum with two inner polyethylene bags; custom packaging available for small quantities

Các câu hỏi thường gặp

What is the minimum order quantity (MOQ) for praziquantel?

Our standard MOQ is 1 kg. For larger volumes, we offer competitive pricing and can accommodate custom order sizes.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is provided with every shipment. Samples are available upon request and are typically dispatched within 1-2 days.

What is the delivery time for stock orders?

We maintain sufficient stock of praziquantel to ensure a lead time of 3-5 business days from order confirmation.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.