Ketoprofen

Từ đồng nghĩa: 2-(3-Benzoylphenyl)propionic acid, (±)-Ketoprofen, Orudis, Oruvail, Actron, 22071-15-4

Ketoprofen belongs to the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAIDs), distinguished by a 3-benzoylphenyl substituent on the propionic acid backbone. This structural motif enhances lipophilicity and facilitates rapid penetration into synovial fluid, where the drug reaches concentrations approaching those in plasma. The molecule exists as a racemic mixture, but pharmacological activity resides almost entirely in the S-enantiomer, which reversibly inhibits cyclooxygenase (COX) enzymes and thereby reduces prostaglandin synthesis.

First introduced in the 1970s, ketoprofen remains a mainstay in both human and veterinary medicine for its potent analgesic, antipyretic, and anti-inflammatory effects. It is supplied as a high-purity active pharmaceutical ingredient (API) that meets current pharmacopeial monographs, including USP, EP, and BP. Our ketoprofen is manufactured under cGMP conditions and is available in both racemic and enantiopure forms to support formulation development.

Formulators value ketoprofen for its favorable balance of efficacy and tolerability, as well as its compatibility with a range of dosage forms—from immediate-release tablets and capsules to topical gels and transdermal patches. In the research setting, it serves as a reference compound for COX inhibition studies and as a precursor for prodrug design. The following sections provide technical details on its properties, mechanism, quality control, and supply.

Cấu trúc và tính chất hóa học

Ketoprofen is a chiral 2-arylpropionic acid derivative with the molecular formula C16H14O3 and a molecular weight of 254.28 g/mol. The molecule contains a benzophenone moiety, which contributes to its UV absorbance and photolability. It is a white to off-white crystalline powder, practically insoluble in water but freely soluble in common organic solvents such as ethanol, acetone, and chloroform. The pKa is approximately 4.5, and the octanol-water partition coefficient (log P) is around 3.1, reflecting its moderate lipophilicity. Ketoprofen exhibits polymorphism, and the crystalline form can influence dissolution rate and stability; therefore, our API is routinely characterized by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) to ensure consistent solid-state properties.

Cơ chế tác dụng

• COX inhibition: Ketoprofen reversibly inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), enzymes responsible for converting arachidonic acid to prostaglandin H2, the precursor of prostaglandins and thromboxanes.
• Prostaglandin suppression: By blocking COX, ketoprofen reduces the production of prostaglandins that sensitize peripheral nociceptors and mediate inflammation, thereby alleviating pain and swelling.
• Lipoxygenase pathway: Unlike some NSAIDs, ketoprofen also inhibits the lipoxygenase pathway, reducing leukotriene synthesis, which may contribute to its anti-inflammatory profile.
• Central sensitization: Ketoprofen penetrates the central nervous system and may attenuate central prostaglandin-mediated pain processing, adding to its analgesic effect.
• Enantioselective activity: The S-enantiomer is primarily responsible for COX inhibition, while the R-enantiomer lacks significant COX activity but may contribute to other mechanisms.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Công suất: Annual production capacity of 50 metric tons, with flexible batch sizes from 1 kg to 500 kg to support both pilot and commercial-scale needs.
• Thời gian thực hiện: 3-5 business days for stock items, shipped from our warehouse upon order confirmation.
• Tài liệu hướng dẫn: A comprehensive documentation package is provided, including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and regulatory support documents such as DMF and CEP upon request.
• Bao bì: Standard packaging is 25 kg net in fiber drums with double polyethylene liners. Custom packaging options, including 1 kg, 5 kg, and 10 kg aliquots, are available to accommodate varying order quantities.

Các câu hỏi thường gặp

What is the minimum order quantity (MOQ) for ketoprofen?

We offer flexible MOQs starting from 1 kg for research and development purposes. For commercial orders, we can accommodate quantities up to 500 kg per batch. Please contact our sales team to discuss your specific requirements.

What is the typical delivery time?

For stock items, the lead time is 3-5 business days from order confirmation. We maintain sufficient inventory to ensure prompt shipment and can provide expedited shipping options if needed.

Can you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is available for each batch upon request. We also provide free samples (typically 10-50 g) for evaluation, with the recipient covering shipping costs. Samples are dispatched within 1-2 days after request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.