Probenecid Sodium

Синонимы: Sodium 4-(dipropylsulfamoyl)benzoate, Probenecid sodium salt, p-(Dipropylsulfamoyl)benzoic acid sodium salt, 4-(Dipropylsulfamoyl)benzoic acid sodium salt, Benzoic acid, 4-[(dipropylamino)sulfonyl]-, sodium salt

Probenecid Sodium is the sodium salt of probenecid, a sulfonamide derivative that acts as a uricosuric agent. It appears as a white to off-white crystalline powder and is supplied in pharmaceutical grades suitable for oral and parenteral formulations. The sodium salt form offers improved aqueous solubility compared to the free acid, making it easier to incorporate into liquid dosage forms.

Our Probenecid Sodium is manufactured under cGMP conditions and is available with assay ≥99.0% by HPLC. It is typically used as an active pharmaceutical ingredient (API) in medications for gout and hyperuricemia, and as a component in combination therapies to enhance the plasma levels of co-administered drugs.

Formulators incorporate Probenecid Sodium into tablets, capsules, and injectable solutions. Its high water solubility makes it particularly suitable for liquid-filled capsules and sterile injectables. The compound is also used in research settings as a reference standard and in the development of sustained-release formulations.

Applications & Formulation Use

Probenecid Sodium is primarily used in the treatment of chronic gout and gouty arthritis, where it increases urinary excretion of uric acid. In combination regimens, it is employed as an adjunct to prolong the action of certain antibiotics, such as penicillins and cephalosporins, by inhibiting their renal tubular secretion. This makes it valuable in therapies requiring sustained antibiotic levels.

In pharmaceutical development, the sodium salt is preferred for parenteral formulations due to its rapid dissolution in aqueous media. It is also used in clinical research as a probe for studying renal transport mechanisms and drug-drug interactions. Formulators often select Probenecid Sodium for oral solutions and suspensions where the free acid’s limited solubility would be a constraint.

Sourcing & Production

Probenecid Sodium is synthesized through a multi-step chemical process starting from p-carboxybenzenesulfonamide, which is reacted with dipropylamine to form probenecid, followed by neutralization with sodium hydroxide to yield the sodium salt. The manufacturing process is carried out under strict cGMP controls to ensure high purity and consistency. Our product is produced in FDA-approved facilities and is available with full regulatory support.

The production route avoids the use of hazardous solvents, and the final product is isolated by crystallization and dried to a stable crystalline form. Each batch is tested for identity, assay, and solubility to meet pharmacopeial requirements. We supply Probenecid Sodium in various package sizes to accommodate both small-scale development and commercial production.

Bulk Supply & Documentation

• Packaging: 1 kg, 5 kg, 25 kg
• MOQ: 1 kg
• Срок выполнения заказа: 3-5 business days
• Documentation: COA and MSDS with every shipment; TDS on request

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room,5-0203, Unit 5, Beiyuanmen Street,Xi’an,Shaanxi,China
• Email: info@lyvbio.com
• Phone/WA: +86-182-9185-7498

send us your specification for a quotation.