Guanfacine

Синонимы: N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide, Guanfacine hydrochloride, Estulic, Tenex, Intuniv, 29110-47-2

Guanfacine has become a molecule of interest for formulators targeting noradrenergic signaling, particularly in the wake of demand for non-stimulant options in ADHD therapy and adjunctive treatments for hypertension. Its selectivity for alpha-2A adrenergic receptors sets it apart from older centrally acting antihypertensives, and this pharmacological edge drives steady sourcing from pharmaceutical and research buyers.

Chemically, guanfacine is a dichlorophenylacetamide derivative that functions as a centrally acting alpha-2 adrenergic agonist. The compound is synthesized through a multi-step route starting from 2,6-dichlorobenzeneacetic acid, yielding the free base or its hydrochloride salt depending on the intended formulation. Its ability to modulate norepinephrine release without the sedative burden of clonidine has positioned it as a preferred API for extended-release dosage forms.

LyvBio supplies guanfacine with a minimum assay of 99.0% (HPLC), suitable for both generic drug development and reference standard applications. Each batch is manufactured under cGMP conditions, with full traceability from raw material to final packaging. The product is available in kilogram to multi-ton quantities, supported by comprehensive documentation for regulatory filings.

Product Overview & Composition

Guanfacine is a white to off-white crystalline powder with a molecular weight of 246.09 g/mol. It is freely soluble in water and methanol, making it adaptable to a range of oral solid and liquid formulations. The compound is typically supplied as the free base or hydrochloride salt, with the free base form offering flexibility for salt selection during early development.

The active pharmaceutical ingredient is characterized by a high degree of purity, with related substances controlled to stringent limits. This ensures consistent performance in both immediate-release and extended-release matrices, where even minor impurities can affect release kinetics.

Applications & Product Lines

• ADHD therapeutics: Used as a non-stimulant option in extended-release tablets, often prescribed when stimulant tolerability is a concern.
• Hypertension management: Incorporated into immediate-release formulations for blood pressure control via central alpha-2A agonism.
• Research compounds: Employed in pharmacological studies investigating noradrenergic pathways and prefrontal cortex function.
• Generic drug development: Serves as the API for ANDA submissions, requiring tight control of polymorphic form and particle size.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: 25 kg net weight in fiber drums with double polyethylene liners, or as customized.
• MOQ: 1 kg for pilot scale, 25 kg for commercial orders.
• Срок выполнения заказа: 3-5 business days for stock items.
• Documentation: COA, MSDS, TDS, and regulatory support documents available upon request.

Frequently Asked Questions

What is the minimum order quantity for guanfacine?

Our MOQ is 1 kg for pilot-scale trials and 25 kg for commercial orders. Larger quantities can be accommodated with scheduled production.

How long does delivery take?

For stock items, delivery is 3-5 business days from order confirmation. We maintain inventory to ensure rapid dispatch.

Can you provide a COA and sample?

Yes, a COA is included with every shipment, and samples are available for evaluation. Sample dispatch typically takes 1-2 days after request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.