Osthole

Синонимы: Cnidium monnieri extract, Osthole, 7-Methoxy-8-isopentenylcoumarin, Osthol, 8-Isopentenyl-7-methoxycoumarin, Cnidium lactone, Selinum monnieri extract.

Osthole is a prenylated coumarin (7-methoxy-8-isopentenylcoumarin) isolated from the fruits of Cnidium monnieri (L.) Cusson, a plant used in traditional Chinese medicine. Its structure combines a coumarin core with an isopentenyl side chain, giving it lipophilic character and the ability to interact with multiple biological targets. The compound appears as white to off-white crystals and is typically standardized to ≥98% purity by HPLC for pharmaceutical and research applications.

As a natural product, osthole has drawn interest for its diverse pharmacological activities, including anti-inflammatory, osteogenic, neuroprotective, and antimicrobial effects. These properties make it a valuable intermediate for drug discovery and a functional ingredient in dietary supplements and cosmetic formulations. Its ability to modulate signaling pathways such as Wnt/β-catenin and NF-κB has been extensively studied in preclinical models.

Osthole is available in high-purity grades suitable for use as an analytical standard, in in vitro and in vivo research, and as a starting material for semi-synthetic derivatives. Its well-defined chemistry and reproducible profile support consistent results across applications.

Chemical Structure & Properties

Osthole (C15H16O3) is a coumarin derivative with a methoxy group at position 7 and an isopentenyl chain at position 8. This substitution pattern enhances its lipophilicity, facilitating cell membrane penetration. It is soluble in organic solvents like ethanol and DMSO but has low aqueous solubility. The compound exhibits UV absorption maxima around 322 nm, useful for HPLC detection.

Механизм действия

• Wnt/β-catenin signaling: Osthole promotes osteoblast differentiation by activating the Wnt/β-catenin pathway, supporting bone formation.
• NF-κB inhibition: It suppresses NF-κB activation, reducing pro-inflammatory cytokine production.
• Phosphodiesterase inhibition: Osthole inhibits PDE4, increasing cAMP levels and modulating smooth muscle tone.
• Antimicrobial activity: It disrupts bacterial cell membranes and inhibits biofilm formation.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 500 kg per month
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double PE bags inside, or as per customer requirements

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Osthole?

Our standard MOQ is 1 kg, but we can accommodate smaller quantities for research purposes. Please contact us for details.

How long does delivery take?

For stock items, delivery is typically 3-5 business days after order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch and can supply samples for quality evaluation. Sample delivery usually takes 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.