Acetyl Tetrapeptide-11

Acetyl Tetrapeptide-11

Название продукта Acetyl Tetrapeptide-11
Номер CAS 928006-88-6
Синонимы Acetyl Tetrapeptide-11, N-Acetyl-L-alanyl-L-prolyl-L-valyl-L-histidine, Acetyl-Ala-Pro-Val-His
Молекулярная формула C22H33N7O6
Молекулярная масса 491.54 g/mol
Внешний вид White to off-white powder
Анализ (ВЭЖХ) ≥98.0%
Растворимость Soluble in water, ethanol
Упаковка 1 kg, 5 kg, 10 kg (inner double PE bags, outer fiber drum)

Acetyl Tetrapeptide-11 Structure

Синонимы: Acetyl Tetrapeptide-11, N-Acetyl-L-alanyl-L-prolyl-L-valyl-L-histidine, Acetyl-Ala-Pro-Val-His, Acetyl Tetrapeptide-11 (INCI)

Acetyl Tetrapeptide-11 is a synthetic tetrapeptide with the sequence N-acetyl-alanyl-prolyl-valyl-histidine. The N-terminal acetyl group protects the peptide from enzymatic degradation, enhancing its stability and bioavailability in topical formulations. This modification is common in cosmeceutical peptides, allowing them to remain active on the skin for longer periods.

Unlike natural peptides that often suffer from rapid breakdown, Acetyl Tetrapeptide-11 is designed for robustness. It belongs to a class of biomimetic peptides that mimic natural growth factors or signaling molecules. The histidine residue contributes to its buffering capacity and potential metal-binding properties, while the alanine and valine residues provide hydrophobic characteristics that influence its interaction with lipid bilayers.

In the personal care industry, Acetyl Tetrapeptide-11 is primarily used as an anti-aging active. It is incorporated into skincare products targeting firmness, elasticity, and overall skin tone. The peptide works by supporting the skin’s natural repair mechanisms, particularly by stimulating collagen synthesis and protecting against glycation, a process that stiffens skin proteins and leads to visible signs of aging.

Our Acetyl Tetrapeptide-11 is manufactured using solid-phase peptide synthesis (SPPS) and purified via preparative HPLC to achieve high purity. It is supplied as a white to off-white powder, readily soluble in water and ethanol, making it suitable for a variety of cosmetic formulations, including serums, creams, and lotions. Each batch is tested for identity, purity, and residual solvents to ensure consistent performance.

Функция

  • Collagen stimulation: Promotes collagen I and III synthesis, improving skin firmness and reducing wrinkles.
  • Anti-glycation: Inhibits the formation of advanced glycation end-products (AGEs), protecting skin proteins from cross-linking.
  • Skin repair: Enhances keratinocyte proliferation and migration, supporting the skin barrier.
  • Antioxidant activity: Scavenges free radicals, reducing oxidative stress in skin cells.
  • Противовоспалительное: Modulates inflammatory cytokines, soothing irritated skin.

Source & Standardization

  • Source: Synthetic peptide produced by solid-phase peptide synthesis.
  • Extraction: Not applicable; chemically synthesized.
  • Standardization: ≥98.0% (HPLC).
  • Forms: White to off-white powder.
  • Приложения: Anti-aging serums, creams, lotions, eye care products.

Технические характеристики

Параметр Технические характеристики
Анализ (ВЭЖХ) ≥98.0%
Идентификация Matches standard
Потери при сушке ≤5.0%
Остаток после прокаливания ≤0,51 TP3T
Тяжелые металлы ≤10 ppm
Microbial Limits Total aerobic count ≤1000 CFU/g; Yeast & Mold ≤100 CFU/g; E. coli absent

Documentation & Supply

  • Monthly capacity: 50 kg
  • Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
  • Documentation: COA, MSDS, TDS available upon request
  • Packaging: 1 kg, 5 kg, 10 kg in double PE bags inside fiber drums

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