Vitamin K2 (MK4)

Synonyms: Menaquinone-4, Vitamin K2, MK-4, Menatetrenone, 2-Methyl-3-all-trans-tetraprenyl-1,4-naphthoquinone, Vitamin K2 (MK4)

Vitamin K2 (MK4) has become a key ingredient for formulators targeting bone and cardiovascular health. Unlike the more common MK-7, MK-4 is a short-chain menaquinone with a distinct pharmacokinetic profile—rapid absorption and quick tissue distribution. Its popularity surged after Japan approved menatetrenone for osteoporosis treatment, and it now appears in premium bone health supplements, cardiovascular support formulas, and functional foods.

Chemically, MK-4 is a naphthoquinone with a four-unit isoprenoid side chain. It occurs naturally in animal products like egg yolk, liver, and butter, but commercial production relies on chemical synthesis to achieve high purity. At LyvBio, we supply synthetic MK-4 with ≥98% purity (HPLC), ensuring consistent quality for your formulations.

Product Overview & Composition

Vitamin K2 (MK4) is a fat-soluble vitamin essential for activating osteocalcin and matrix Gla protein, which regulate calcium deposition in bones and arteries. Its mechanism involves gamma-carboxylation of glutamate residues in these proteins, enhancing their calcium-binding capacity. This makes MK-4 particularly valuable for bone mineral density and arterial elasticity.

Our MK-4 is synthesized through a multi-step process, yielding a crystalline powder that is standardized to ≥98% purity. It is available in various packaging sizes to suit your production needs.

Applications & Product Lines

• Bone health supplements: Often combined with calcium and vitamin D3 to support bone density.
• Cardiovascular support: Used in formulas aimed at preventing arterial calcification.
• Functional foods: Added to dairy products, beverages, and bars for bone health benefits.
• Clinical nutrition: Included in medical foods for patients with osteoporosis or vitamin K deficiency.
• Cosmeceuticals: Emerging use in skin care for its potential anti-aging effects.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: 1 kg, 5 kg, 10 kg, 25 kg drums with inner LDPE bags
• MOQ: 1 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our MOQ for Vitamin K2 (MK4) is 1 kg. For larger quantities, we offer competitive pricing and flexible packaging options.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation. We ship globally via express couriers and air freight.

Can I get a COA and sample?

Yes, we provide a COA for each batch. Samples are available upon request; please contact our sales team for details.

What packaging options do you offer?

We offer 1 kg, 5 kg, 10 kg, and 25 kg drums. Custom packaging can be arranged for bulk orders.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.