Valsartan

Synonyms: Valsartan, 137862-53-4, Diovan, Tareg, Exforge, CGP 48933, Valsartanum

Valsartan has become a staple in the generic cardiovascular market, with global demand driven by its well-established efficacy in hypertension and heart failure. As the patent exclusivity expired years ago, manufacturers and formulators are now focused on sourcing high-quality API from reliable suppliers to meet the growing needs of healthcare systems worldwide.

Valsartan is a non-peptide angiotensin II receptor blocker (ARB) that selectively antagonizes the AT1 receptor subtype. It is chemically described as N-(1-oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine. The molecule is synthesized through a multi-step process, resulting in a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents.

Our Valsartan is manufactured under cGMP conditions and standardized to ≥99.0% purity (HPLC). It is available in various particle sizes to suit different formulation needs, from immediate-release tablets to fixed-dose combinations. With a focus on consistency and regulatory compliance, we serve pharmaceutical companies seeking a dependable API source.

Product Overview & Composition

Valsartan is a small-molecule API belonging to the biphenyl tetrazole class. Its structure features a tetrazole ring that mimics the imidazole ring of angiotensin II, allowing it to block the AT1 receptor and thereby reduce vasoconstriction and aldosterone release. The API is typically supplied as the free acid, which is the active moiety in finished dosage forms.

The manufacturing process involves several synthetic steps, including amide bond formation and tetrazole ring construction. Strict control of reaction parameters ensures low levels of process-related impurities, such as the desvaleryl impurity and other specified degradants. Each batch is tested for identity, assay, and impurity profile to meet pharmacopeial requirements.

Applications & Product Lines

• Hypertension: Valsartan is a first-line treatment for essential hypertension, often used alone or in combination with diuretics or calcium channel blockers.
• Heart Failure: It is indicated to reduce cardiovascular mortality in patients with heart failure and left ventricular dysfunction.
• Post-Myocardial Infarction: Valsartan is used to improve survival in clinically stable patients with left ventricular failure after myocardial infarction.
• Fixed-Dose Combinations: Frequently formulated with hydrochlorothiazide, amlodipine, or sacubitril for enhanced efficacy and patient compliance.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: 25 kg fiber drums with double polyethylene liners, or as per customer requirements.
• MOQ: 25 kg.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and regulatory support available upon request.

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Valsartan?

Our standard MOQ is 25 kg. For smaller quantities, please contact us to discuss your specific needs.

What is the typical lead time for an order?

Lead time is generally 3-5 business days after order confirmation, depending on the quantity and destination.

Can you provide a COA and sample for evaluation?

Yes, we provide a COA for each batch and can supply samples for quality evaluation. Please reach out to our sales team for arrangements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

Learn more about our quality control and certifications, or send us your specification for a quotation.