Toosendanin

Synonyms: Melia toosendan Extract, Chinaberry Extract, Toosendan Fructus Extract, Sendanin, 28-Deacetyltoosendanin

Toosendanin is a tetranortriterpenoid isolated from the fruit and bark of Melia toosendan Sieb. et Zucc. (Meliaceae). Its structure features a highly oxidized 4,4,8-trimethyl-17-furanyl steroid skeleton with multiple hydroxyl and acetoxy groups, which underpin its electron-donating and metal-chelating properties. The compound is known to interact with voltage-gated calcium channels and presynaptic release machinery, a mechanism that has drawn interest in both insect physiology and neuropharmacology.

Commercial Toosendanin is supplied as a high-purity crystalline solid (≥98% by HPLC), typically derived from solvent extraction of dried fruits followed by repeated chromatography. It is a reference-grade material for analytical method development, a tool compound for ion-channel studies, and an active ingredient in botanical insecticide formulations. Unlike crude botanical extracts, this single-molecule product offers consistent potency and traceable purity.

In industrial settings, Toosendanin serves as a standard for quality control of Melia-based raw materials and as a starting point for semi-synthetic derivatives. Its dual role as a natural insect antifeedant and a pharmacological probe makes it relevant to crop protection, veterinary research, and basic neuroscience.

Chemical Structure & Properties

Toosendanin (C30H38O11) is a white to off-white crystalline powder with a molecular weight of 574.62 g/mol. The molecule contains a furan ring, several acetyl groups, and a lactone moiety, contributing to its moderate polarity. It is soluble in methanol, ethanol, and DMSO, but only slightly soluble in water. The compound is stable under normal storage conditions but should be protected from light and moisture to prevent hydrolysis of the acetyl groups.

Mechanism of Action

• Calcium channel modulation: Toosendanin blocks L-type and T-type voltage-gated calcium channels, altering intracellular calcium homeostasis in excitable cells.
• Presynaptic transmitter release: It inhibits evoked neurotransmitter release at neuromuscular junctions, likely by interfering with synaptotagmin-mediated membrane fusion.
• Insect antifeedant activity: The compound deters feeding in lepidopteran larvae by disrupting chemosensory signaling and causing midgut epithelial damage.
• Apoptosis induction: In certain cancer cell lines, Toosendanin triggers mitochondrial-dependent apoptosis through Bax/Bcl-2 modulation.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: Up to 500 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and certified analysis reports available upon request
• Packaging: 25 kg fiber drum with double PE liner; custom packaging options for small quantities

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our standard MOQ is 1 kg. For research or trial purposes, we can accommodate smaller quantities; please contact our sales team for details.

What is the delivery time?

For stock items, delivery is 3-5 business days from order confirmation.

Can you provide a COA and samples?

Yes, a certificate of analysis (COA) is available for each batch. Samples can be provided for evaluation; please specify your requirements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.