Theophylline

Synonyms: Theophylline, 1,3-Dimethylxanthine, Theophylline anhydrous, 58-55-9, Theo-Dur, Uniphyl, Elixophyllin.

Theophylline is a naturally occurring methylxanthine alkaloid found in tea leaves and cacao beans, and it is produced synthetically for pharmaceutical use. Chemically, it is 1,3-dimethylxanthine, a close structural relative of caffeine and theobromine. Its bronchodilator properties have been recognized since the early 20th century, and it remains a key active pharmaceutical ingredient in respiratory care.

As a phosphodiesterase inhibitor and adenosine receptor antagonist, theophylline relaxes bronchial smooth muscle, improves diaphragmatic contractility, and reduces airway responsiveness to allergens. Its narrow therapeutic window demands high-purity material, making theophylline API a critical component in both immediate-release and sustained-release oral dosage forms.

At LyvBio, theophylline is supplied as a fine crystalline powder with an assay of 99.0%–101.0% (HPLC). Our production follows cGMP guidelines, and every batch is accompanied by a comprehensive Certificate of Analysis. The material is suitable for formulation into tablets, capsules, and oral solutions for the management of asthma and COPD.

Function & Mechanism

• Bronchodilation: Inhibits phosphodiesterase, increasing cyclic AMP and relaxing bronchial smooth muscle.
• Adenosine antagonism: Blocks adenosine A1 and A2 receptors, reducing bronchoconstriction and mast cell mediator release.
• Anti-inflammatory: At lower doses, modulates inflammatory cell activity and reduces airway edema.
• Respiratory stimulation: Enhances diaphragmatic contractility and improves mucociliary clearance.
• Cardiovascular effects: Mild positive inotropic and chronotropic actions at therapeutic concentrations.

Source & Standardization

• Source: Synthetic, derived from dimethylurea and ethyl acetoacetate or via methylation of xanthine.
• Manufacturing: Controlled chemical synthesis followed by recrystallization and drying.
• Standardization: Assay 99.0%–101.0% (HPLC); meets EP, USP, and BP monographs.
• Forms: White to off-white crystalline powder.
• Applications: Oral solid dosage forms, sustained-release tablets, injections, and research.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 5 metric tons
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and cGMP declaration available upon request.
• Packaging: 25 kg fiber drums with double polyethylene liners, or customized packaging.

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our standard MOQ is 1 kg. For larger quantities, we offer competitive pricing and flexible shipping options.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation. We ship globally via express couriers or air freight.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is provided with every shipment. Samples are available for quality evaluation; please contact our sales team for arrangements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.