Tetrahydropiperine

Synonyms: 1-Piperoylpiperidine, Tetrahydropiperine, THP, (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one, Piperine tetrahydride

Tetrahydropiperine (THP) is a synthetic derivative of piperine, the pungent alkaloid found in black pepper (Piper nigrum). While piperine itself has limited stability and solubility, THP offers improved bioavailability and a milder sensory profile, making it a preferred choice for formulators seeking the bioavailability-enhancing benefits of piperine without its drawbacks.

As a bioavailability enhancer, THP is widely used in dietary supplements to improve the absorption of nutrients such as curcumin, resveratrol, and CoQ10. Its mechanism involves inhibition of intestinal P-glycoprotein and cytochrome P450 enzymes, which are responsible for the efflux and metabolism of many xenobiotics. This results in higher plasma concentrations of co-administered compounds. THP is also explored for its potential anti-inflammatory and antioxidant properties, though its primary commercial role remains as an absorption enhancer.

Product Highlights

• High Purity: ≥98% by HPLC, ensuring consistent performance in formulations.
• Improved Stability: More stable than piperine under various pH and temperature conditions.
• Mild Taste: Reduced pungency compared to piperine, suitable for taste-sensitive applications.
• Regulatory Support: Manufactured under cGMP conditions; available with full documentation.
• Scalable Supply: Bulk quantities available with short lead times.

Applications & Formulation Use

• Bioavailability Enhancement: Used in combination with curcumin, resveratrol, and other poorly absorbed nutraceuticals.
• Sports Nutrition: Included in pre-workout and recovery formulas to enhance uptake of creatine and amino acids.
• Weight Management: Added to thermogenic blends to improve absorption of green tea catechins and other actives.
• Pharmaceutical Research: Investigated as a P-gp inhibitor in drug delivery studies.

Quality Specifications (QC Tests)

Bulk Supply & Ordering

• Packaging: 25 kg fiber drum with double polyethylene liner, or as per customer request.
• MOQ: 1 kg for trial orders; 25 kg for bulk orders.
• Lead time: 3-5 business days for stock items.
• Documentation: COA, MSDS, TDS available upon request.

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our MOQ is 1 kg for trial orders and 25 kg for bulk orders. Custom packaging and quantities can be arranged.

What is the delivery time?

For stock items, delivery is within 3-5 business days after order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request, typically shipped within 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.