Selamectin

Synonyms: Selamectin, UK-124, 220119-17-5, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)avermectin B1 monosaccharide, Pfizer UK-124, Revolution

Selamectin is a semi-synthetic avermectin derivative developed by Pfizer for veterinary parasitology. It belongs to the macrocyclic lactone class and is structurally related to ivermectin, but with a unique cyclohexyl substitution and a hydroxyimino group at the 5-position. This modification enhances its spectrum of activity and duration of effect, making it a mainstay in companion animal medicine.

First approved in 1999 under the trade name Revolution, Selamectin is a topical endectocide effective against a broad range of internal and external parasites in dogs and cats, including fleas, ticks, ear mites, sarcoptic mange, and heartworm. Its mechanism involves binding to glutamate-gated chloride channels, leading to paralysis and death of parasites. The compound is also used in research on anthelmintic resistance and neuropharmacology.

As a high-purity active pharmaceutical ingredient (API), Selamectin is supplied with a typical assay ≥98.0% (HPLC). It appears as a white to off-white crystalline powder, soluble in organic solvents such as ethanol and DMSO but practically insoluble in water. Our material is manufactured under cGMP conditions and is available for formulation into topical spot-on solutions, injectables, and oral dosage forms.

Function & Mechanism

• Glutamate-gated chloride channel activation: Binds to GluCl channels in invertebrate nerve and muscle cells, causing hyperpolarization and paralysis.
• Broad-spectrum antiparasitic: Effective against nematodes, insects, and acarines, including fleas, ticks, mites, and heartworm larvae.
• Long-acting residual activity: The cyclohexyl group extends the half-life, allowing monthly dosing in companion animals.
• GABA receptor interaction: At higher concentrations, may also act on GABA-gated chloride channels, contributing to its neurotoxic effects in parasites.
• Ovicidal and larvicidal: Disrupts egg hatching and larval development, reducing environmental contamination.

Source & Standardization

• Source: Semi-synthetic derivative of avermectin B1, produced by fermentation of Streptomyces avermitilis followed by chemical modification.
• Extraction: Fermentation, isolation, and multi-step chemical synthesis.
• Standardization: ≥98.0% Selamectin (HPLC), with individual impurities controlled.
• Forms: White to off-white crystalline powder.
• Applications: Veterinary parasiticides, research on anthelmintic resistance, neuropharmacology studies.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, cGMP certificate
• Packaging: 1 kg, 5 kg, 25 kg fiber drums with double LDPE liners

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Selamectin?

Our standard MOQ is 1 kg, but we can accommodate smaller quantities for research purposes. Please contact us for details.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request, typically shipped within 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.