Piroctone Olamine

Synonyms: Piroctone Olamine, Piroctone ethanolamine salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone monoethanolamine salt, Octopirox, 68890-66-4

Piroctone Olamine is a synthetic hydroxamic acid derivative that has become a workhorse antimicrobial in both personal care and pharmaceutical formulations. It is the ethanolamine salt of piroctone acid, a compound first developed in the 1970s as a more tolerable alternative to zinc pyrithione. Unlike many early anti-dandruff actives, it combines broad-spectrum efficacy with an excellent safety profile, making it suitable for leave-on and rinse-off products alike.

Chemically, the molecule features a 2-pyridone ring with a hydroxamic acid moiety, which is responsible for its metal-chelating and antimicrobial properties. This structure allows it to interfere with iron-dependent enzymes in fungi and bacteria, disrupting their energy metabolism and membrane integrity. The ethanolamine salt form enhances water solubility compared to the free acid, simplifying incorporation into aqueous systems.

In commercial settings, Piroctone Olamine is typically standardized to ≥98% purity (HPLC) and is supplied as a fine white powder. Its primary use is in anti-dandruff shampoos, conditioners, and scalp treatments, often at concentrations between 0.1% and 1.0%. It is also found in soaps, deodorants, and cosmetic preservative blends, where it helps control odor-causing bacteria. For B2B buyers, the compound is valued for its stability, compatibility with common surfactants, and regulatory acceptance in major markets.

Beyond scalp care, formulators use Piroctone Olamine in veterinary products and medical devices for its residual activity against Malassezia and Gram-positive bacteria. Its low irritation potential makes it a preferred choice for sensitive-skin applications. As a supplier, we ensure each batch meets stringent quality standards, supported by comprehensive documentation for seamless integration into your production line.

Function

• Antimicrobial activity: Effectively inhibits Malassezia globosa, Staphylococcus aureus, and other skin flora.
• Anti-dandruff: Reduces scalp flaking and itching by targeting fungal overgrowth.
• Preservative booster: Enhances the efficacy of conventional preservatives in cosmetic formulations.
• Deodorant action: Controls odor-causing bacteria without disturbing natural skin microbiome.
• Sebum regulation: Helps normalize oil production in scalp and facial care products.

Source & Standardization

• Source: Synthetic, derived from 2,4,4-trimethylpentyl-substituted pyridone.
• Production: Chemical synthesis followed by salt formation with ethanolamine and recrystallization.
• Standardization: ≥98.0% assay (HPLC), consistent particle size distribution.
• Forms: White to off-white crystalline powder.
• Applications: Anti-dandruff shampoos, conditioners, deodorants, cosmetic preservatives, veterinary hygiene.

Specifications

Documentation & Supply

• Monthly capacity: 20 metric tons
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and regulatory support available upon request
• Packaging: 25 kg fiber drums with double PE liners; custom packaging options for small quantities

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com