Palmitoyl Tripeptide-5

Synonyms: Palmitoyl Tripeptide-5, Pal-GHK, Palmitoyl-Gly-His-Lys, Palmitoyl Tripeptide-5, Matrixyl, Tripeptide-5, Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-5 is a synthetic lipopeptide featuring a palmitic acid moiety conjugated to the N-terminus of a tripeptide sequence (glycine-histidine-lysine). This structural design enhances lipophilicity, facilitating penetration through the stratum corneum and delivery to deeper skin layers where it interacts with fibroblasts. The peptide acts as a signaling molecule, upregulating collagen synthesis and promoting extracellular matrix remodeling, key processes in skin aging and repair.

Commercially, Palmitoyl Tripeptide-5 is produced via solid-phase peptide synthesis, followed by N-terminal palmitoylation. It is typically supplied as a white to off-white powder with high purity (≥98% by HPLC) and is soluble in water and common cosmetic solvents. The ingredient is widely used in anti-aging and anti-wrinkle formulations, often in concentrations ranging from 2% to 5% in finished products.

Research indicates that Palmitoyl Tripeptide-5 stimulates collagen I, III, and fibronectin production in vitro, and clinical studies have shown improvements in skin firmness and reduction of fine lines. Its efficacy and favorable safety profile make it a preferred active in premium skincare lines. For B2B buyers, LyvBio offers consistent quality with full documentation and reliable supply.

Chemical Structure & Properties

Palmitoyl Tripeptide-5 is a linear lipopeptide with the sequence palmitoyl-Gly-His-Lys. The palmitoyl group (C16:0) is attached to the glycine residue, contributing to the molecule’s amphiphilic nature. The tripeptide portion includes histidine and lysine, which can participate in hydrogen bonding and electrostatic interactions. The molecular formula is C₃₆H₆₈N₆O₅, with a molecular weight of 665.0 g/mol. It appears as a white to off-white powder, freely soluble in water, ethanol, and propylene glycol. The compound is stable under recommended storage conditions (2-8°C, protected from light and moisture).

Mechanism of Action

• Collagen stimulation: Palmitoyl Tripeptide-5 upregulates collagen synthesis in fibroblasts by mimicking the natural procollagen I N-terminal propeptide, thereby promoting extracellular matrix production.
• Anti-wrinkle effect: By enhancing collagen and fibronectin levels, it improves skin elasticity and reduces the appearance of fine lines and wrinkles.
• Penetration enhancement: The palmitoyl group increases lipophilicity, allowing the peptide to penetrate the stratum corneum more effectively than non-lipidated peptides.
• MMP inhibition: It may inhibit matrix metalloproteinases (MMPs), enzymes that degrade collagen, further supporting skin matrix integrity.

Quality Specifications

Supply & Documentation

• Capacity: 500 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com