Palmitoyl Tetrapeptide-7

Synonyms: Palmitoyl Tetrapeptide-7, Palmitoyl Tetrapeptide-3 (former name), Matrixyl 3000 component, Pal-GQPR, N-Palmitoyl-Gly-Gln-Pro-Arg

Palmitoyl Tetrapeptide-7 is a synthetic peptide that has become a staple in anti-aging skincare, often paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex. It is a tetrapeptide (Gly-Gln-Pro-Arg) attached to a palmitic acid chain, which enhances its lipophilicity and skin penetration. The peptide was first developed to mimic the natural processes that reduce inflammation and support skin repair, making it a valuable ingredient in formulations targeting visible aging and skin resilience.

Chemically, Palmitoyl Tetrapeptide-7 is a fatty acid-conjugated peptide with the sequence palmitoyl-glycyl-glutaminyl-prolyl-arginine. The palmitoyl group not only improves stability and bioavailability but also allows the peptide to anchor into the lipid layers of the skin. Its primary mechanism involves signaling to the skin to reduce the release of pro-inflammatory cytokines, such as IL-6, which are elevated during environmental stress and aging. By modulating these inflammatory responses, the peptide helps maintain a healthier extracellular matrix and supports the skin’s natural repair mechanisms.

In commercial skincare, Palmitoyl Tetrapeptide-7 is typically used at concentrations between 2-4% in finished products, often combined with other peptides like Palmitoyl Tripeptide-1 to synergistically boost collagen production and firmness. It appears in premium serums, eye creams, and moisturizers aimed at reducing puffiness, dark circles, and fine lines. Beyond cosmetics, it is also studied for its potential in wound healing and anti-inflammatory applications, though its primary market remains dermo-cosmetics.

Function

• Anti-inflammatory activity: Reduces the release of pro-inflammatory cytokines (e.g., IL-6) in the skin, helping to soothe irritation and prevent collagen breakdown.
• Skin firming: Supports the extracellular matrix by promoting the synthesis of collagen and elastin, improving skin elasticity and firmness.
• Anti-aging effect: Diminishes the appearance of fine lines and wrinkles by enhancing skin renewal and resilience.
• Eye contour care: Helps reduce under-eye puffiness and dark circles by calming micro-inflammation and improving microcirculation.

Source & Standardization

• Source: Synthetic peptide, produced via solid-phase peptide synthesis (SPPS)
• Extraction: Not applicable (synthetic origin)
• Standardization: ≥98% peptide purity (HPLC)
• Forms: White to off-white powder
• Applications: Cosmetic formulations (serums, creams, eye care), research studies

Specifications

Documentation & Supply

• Monthly: 50 kg
• MOQ:1-5g
• Lead time: 5-7 days for stock items
• Documentation: COA, MSDS, TDS, allergen statement
• Packaging: Sealed aluminum foil bags or HDPE bottles, 5g, 10g, 25g, custom available

Request For Quote

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• LyvBio Co., Ltd. — Email: info@lyvbio.com