Oxymatrine

Synonyms: Oxymatrine, Matrine N-oxide, Ammothamnine, Sophora flavescens root extract, Kushen extract, C15H24N2O2

Oxymatrine is a quinolizidine alkaloid N-oxide derived from the roots of Sophora flavescens Ait. Its structure features a tetracyclic quinolizidine core with an N-oxide functional group, which enhances its polarity and water solubility compared to matrine. This modification also influences its pharmacokinetic profile and interaction with biological targets, making it a compound of interest in both pharmaceutical and nutraceutical research.

Commercially, oxymatrine is available as a high-purity extract or synthetic derivative, standardized to ≥98% purity (HPLC). It is typically produced through extraction from Sophora flavescens roots followed by purification steps such as crystallization or chromatography. The compound is widely used in antiviral, anti-inflammatory, and hepatoprotective applications, as well as in research on fibrosis and immune modulation.

With its established safety profile and diverse bioactivities, oxymatrine serves as a valuable ingredient in formulations targeting liver health, viral infections, and inflammatory conditions. Its stability and solubility facilitate incorporation into various dosage forms, including tablets, capsules, and injectables.

Chemical Structure & Properties

Oxymatrine (C15H24N2O2) is a white to off-white crystalline powder with a molecular weight of 264.36 g/mol. The N-oxide group confers increased polarity, making it freely soluble in water and ethanol, and slightly soluble in less polar solvents like acetone. It is stable under normal storage conditions but should be protected from light and moisture to prevent degradation. The compound’s quinolizidine skeleton is responsible for its rigid conformation and specific receptor interactions.

Mechanism of Action

• Antiviral activity: Inhibits viral replication by interfering with viral entry and RNA synthesis, particularly against hepatitis B and C viruses.
• Anti-inflammatory effects: Suppresses NF-κB and MAPK signaling pathways, reducing pro-inflammatory cytokine production.
• Hepatoprotection: Protects hepatocytes from oxidative damage and inhibits hepatic stellate cell activation, mitigating liver fibrosis.
• Immune modulation: Regulates T-cell and macrophage functions, balancing Th1/Th2 responses.
• Anti-fibrotic activity: Downregulates TGF-β1 and collagen deposition in fibrotic tissues.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 5 metric tons per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double polyethylene liner, or as per customer requirements

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Oxymatrine?

Our standard MOQ is 1 kg. For larger quantities, please contact our sales team for customized pricing and packaging options.

What is the delivery time?

For stock items, delivery time is 3-5 business days after order confirmation. We ship globally via express or air freight.

Can you provide a COA and samples?

Yes, we provide a Certificate of Analysis (COA) for each batch. Samples are available upon request; please specify your requirements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.