Nitroxinil

Synonyms: 4-Hydroxy-3-iodo-5-nitrobenzonitrile, 3-Iodo-4-hydroxy-5-nitrobenzonitrile, Nitroxynil, Trodax, Nitromid, 4-Cyano-2-iodo-6-nitrophenol

Nitroxinil is a halogenated phenol derivative used as a veterinary anthelmintic, primarily targeting liver flukes and certain nematodes in livestock. First introduced in the 1960s, it remains a mainstay for treating fascioliasis in cattle and sheep, especially where acute infections threaten production. The molecule features a nitrile group, an iodine atom, and a nitro group on a phenolic ring, a combination that drives its potent activity against immature and adult flukes.

Unlike many older flukicides, nitroxinil is not a salicylanilide or a benzimidazole. Its chemical identity places it in a small class of nitrophenol-based anthelmintics, and the iodine substituent is key to its mechanism. The compound is typically supplied as a free phenol or as the meglumine salt for injectable formulations, but the active ingredient itself is a stable, crystalline solid with good shelf life when protected from light and moisture.

For B2B buyers, nitroxinil is valued for its reliable efficacy and relatively low resistance risk in fluke populations. It is not a commodity API like albendazole or ivermectin, so sourcing requires a partner who understands the specific handling and documentation needs of this niche molecule. Our material is manufactured under strict quality control and is suitable for further formulation into injectable solutions.

Function & Mechanism

• Flukicidal activity: Nitroxinil uncouples oxidative phosphorylation in the parasite’s mitochondria, disrupting energy production and leading to rapid fluke death.
• Nematode control: It also shows activity against Haemonchus contortus and other gastrointestinal nematodes, though its primary use is against liver flukes.
• Rapid onset: Therapeutic doses reduce fluke burdens quickly, often within 24–48 hours, which is critical in acute fascioliasis outbreaks.
• Low resistance potential: The unique mode of action reduces cross-resistance with other flukicides, making it a valuable rotation partner.
• Persistent efficacy: A single injection can protect against reinfection for several weeks depending on the formulation and species.

Source & Standardization

• Source: Synthetic chemical, produced via iodination and nitration of p-hydroxybenzonitrile.
• Extraction: Not applicable; fully synthetic small molecule.
• Standardization: ≥98.0% assay by HPLC; identity confirmed by IR and NMR.
• Forms: Pale yellow to light brown crystalline powder.
• Applications: Veterinary injectable solutions for cattle and sheep; research on fluke metabolism.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 500 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double polyethylene liner

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Nitroxinil?

Our standard MOQ is 1 kg, but we can accommodate smaller quantities for research and development purposes. Please contact us for specific requirements.

What is the delivery time?

For stock items, the lead time is 3-5 business days from order confirmation. We ship globally via express couriers.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is provided with every shipment. Samples are available upon request, typically shipped within 1-2 days after confirmation.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.