Nicotinic acid

Synonyms: Niacin, Vitamin B3, Pyridine-3-carboxylic acid, 3-Pyridinecarboxylic acid, Nicotinic acid

Nicotinic acid has become a staple in the nutraceutical and pharmaceutical industries, driven by growing consumer awareness of vitamin B3’s role in energy metabolism and cardiovascular health. As a water-soluble vitamin, it is widely incorporated into multivitamin supplements, functional beverages, and clinical nutrition formulas. Beyond nutrition, its vasodilatory and lipid-modulating properties have made it a subject of ongoing pharmaceutical research, particularly in managed-release formulations.

Chemically, nicotinic acid is a pyridine derivative with a carboxylic acid group at the 3-position. It occurs naturally in small amounts in animal tissues, yeast, and some vegetables, but commercial quantities are produced synthetically. The compound is distinguished from its amide, nicotinamide, by the presence of a free acid group, which gives it distinct physiological effects, including flushing and lipid effects. Its simple structure and well-characterized safety profile make it a reliable active in both dietary supplements and pharmaceutical preparations.

LyvBio supplies nicotinic acid in a high-purity grade suitable for direct compression and encapsulation. Our material is routinely tested to meet USP/EP specifications, with assay values consistently above 99.0%. The crystalline form ensures good flowability and stability, allowing formulators to achieve uniform blends even at low inclusion levels. Whether you are developing a B-complex tablet or a specialized cardiovascular support formula, our nicotinic acid offers the consistency and documentation you need.

Product Overview & Composition

Nicotinic acid (C6H5NO2) is a white crystalline powder with a molecular weight of 123.11 g/mol. It is sparingly soluble in cold water but dissolves readily in hot water and ethanol. The compound is stable under normal storage conditions, though it should be protected from moisture and direct light to prevent degradation. Its melting point range of 236–239 °C serves as a common identity test in pharmacopeial monographs.

As a vitamin B3 form, nicotinic acid is converted in the body to NAD and NADP, coenzymes essential for redox reactions in cellular respiration. This biochemical role underpins its use in energy-boosting supplements and in clinical settings for treating pellagra. In pharmaceutical applications, nicotinic acid is also used for its ability to modulate lipid profiles, although this typically requires higher doses than those used for vitamin supplementation.

Key Applications

• Dietary supplements: Used in multivitamin tablets, capsules, and softgels to support daily vitamin B3 intake, often in combination with other B-complex vitamins.
• Functional foods and beverages: Incorporated into energy drinks, fortified cereals, and meal replacements to enhance nutritional value.
• Pharmaceutical formulations: Employed in prescription and OTC products for cholesterol management and cardiovascular support, with careful dosage control.
• Animal nutrition: Added to animal feed to prevent niacin deficiency and improve growth performance in livestock and poultry.
• Cosmetics: Used in skin care products for its reported ability to improve skin barrier function and reduce hyperpigmentation, though at lower concentrations than in oral applications.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg fiber drums with double polyethylene liners, or as per customer request.
• MOQ: 25 kg.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com