NA-R-ALA-Sodium (R)-alpha-lipoate

Synonyms: Sodium R-alpha-lipoate, R-(+)-α-Lipoic acid sodium salt, Sodium (R)-lipoate, (R)-α-Lipoic acid sodium salt, NA-RALA, RLA sodium

NA-R-ALA has become a go-to ingredient for formulators targeting metabolic health, antioxidant support, and healthy aging. Unlike standard alpha-lipoic acid (ALA), which is a 50/50 mix of R- and S-enantiomers, NA-R-ALA delivers only the naturally occurring R-isomer as a stable sodium salt. This enhanced bioavailability and solubility make it a preferred choice for premium supplements and functional foods.

Alpha-lipoic acid is a naturally occurring dithiol compound that serves as a cofactor for mitochondrial enzymes. The R-enantiomer is the biologically active form, but it is unstable and prone to polymerization. By converting it to the sodium salt, NA-R-ALA offers improved stability, water solubility, and a neutral pH in solution, simplifying formulation into capsules, tablets, and beverages.

Our NA-R-ALA is produced via a proprietary chiral synthesis and enzymatic resolution process, yielding a high-purity product with an enantiomeric excess (ee) of ≥99%. It is standardized to ≥98.0% (HPLC) and meets rigorous quality standards for pharmaceutical and nutraceutical applications.

Product Overview & Composition

NA-R-ALA is the sodium salt of R-alpha-lipoic acid, a chiral molecule with a specific rotation of +110° to +120° (c=1, ethanol). It is manufactured through a multi-step synthesis starting from adipic acid derivatives, followed by chiral resolution to isolate the R-enantiomer. The final product is a white to off-white crystalline powder, freely soluble in water (up to 50 mg/mL) and ethanol, making it ideal for liquid and solid dosage forms.

The compound acts as a powerful antioxidant, regenerating other antioxidants such as glutathione, vitamin C, and vitamin E. It also enhances insulin sensitivity by activating AMPK and improving glucose uptake in muscle cells. These mechanisms underpin its popularity in products aimed at blood sugar management, weight control, and neuroprotection.

Applications & Product Lines

• Dietary supplements: Capsules, tablets, and softgels for metabolic support and antioxidant defense.
• Functional foods & beverages: Fortified drinks, powders, and bars for energy and glucose metabolism.
• Sports nutrition: Pre-workout and recovery formulas to enhance insulin sensitivity and nutrient partitioning.
• Anti-aging & cognitive health: Nootropic and longevity blends targeting mitochondrial function.
• Pharmaceutical research: API for clinical studies on diabetes, neuropathy, and oxidative stress.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: 25 kg fiber drum with double PE liners; custom packaging available upon request.
• MOQ: 1 kg for trial orders; 25 kg for commercial orders.
• Lead time: 3-5 business days for stock items.
• Documentation: COA, MSDS, TDS provided with each shipment.

Frequently Asked Questions

What is the minimum order quantity (MOQ)?

Our MOQ is 1 kg for trial orders and 25 kg for commercial orders. We can accommodate smaller quantities for research purposes.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation. We ship worldwide via express or air freight.

Do you provide COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request, typically shipped within 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888