Myristoyl Hexapeptide-16

Synonyms: Myristoyl Hexapeptide-16, N-Myristoyl hexapeptide-16, Myristoyl hexapeptide-16 (INCI), CAS 959610-54-9

Myristoyl Hexapeptide-16 is a synthetic lipopeptide built on a hexapeptide backbone, acylated at the N-terminus with myristic acid. The sequence—often referenced as Myr-His-Ala-Lys-Val-Arg-Leu—combines a hydrophobic lipid tail with a charged, bioactive peptide core. This molecular architecture is designed to enhance skin penetration and bioavailability, making it a valuable tool in cosmetic and pharmaceutical research.

As a research-grade ingredient, Myristoyl Hexapeptide-16 is produced via solid-phase peptide synthesis, followed by reverse-phase HPLC purification to achieve high purity. It is supplied as a white to off-white powder, readily soluble in water and common cosmetic solvents. The compound is typically standardized to ≥95% purity, with each batch accompanied by a certificate of analysis.

In the laboratory, Myristoyl Hexapeptide-16 is investigated for its role in modulating extracellular matrix components and cellular signaling pathways. Its lipophilic modification allows for improved membrane interaction, making it a subject of interest in studies on skin repair, anti-aging, and wound healing. The peptide is also used as a reference standard in analytical method development.

Chemical Structure & Properties

Myristoyl Hexapeptide-16 features a linear hexapeptide sequence with a myristoyl group attached to the N-terminal amino group. The peptide backbone includes histidine, alanine, lysine, valine, arginine, and leucine residues, contributing to its overall charge and hydrophilicity. The myristoyl chain imparts lipophilicity, facilitating interaction with lipid bilayers. The compound has a molecular weight of approximately 875.14 g/mol and is stable under recommended storage conditions.

Mechanism of Action

• Collagen stimulation: The peptide sequence may upregulate collagen synthesis in fibroblasts, supporting skin matrix integrity.
• Elastin production: It has been shown to promote elastin expression, enhancing skin elasticity.
• Cell proliferation: Myristoyl Hexapeptide-16 can stimulate keratinocyte and fibroblast proliferation, aiding tissue regeneration.
• Anti-inflammatory effects: The peptide may reduce inflammatory cytokines, contributing to a balanced skin environment.

Quality Specifications

Supply & Documentation

• Capacity: Monthly production capacity of 50 kg, scalable for bulk orders.
• Lead time: 3-5 business days (stock items)
• Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and full analytical data (HPLC, MS).
• Packaging: 1 kg, 5 kg in aluminum foil bags; 25 kg in fiber drums. Custom packaging options available.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com